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Xestospongin C

Name: Xestospongin C
Brand: SIGMA

IP3 receptor Inhibitor, film

Synonym(s):

XeC

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About This Item

Linear Formula:

C₂₈ H₅₀ N₂ O₂

CAS Number:

88903-69-9

Molecular Weight:

446.71

UNSPSC Code:

12352200

PubChem Substance ID:

24902138

NACRES:

NA.77

MDL number:

MFCD01862629

Form:

film

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Properties

Product Name

Xestospongin C, film

form

film

Quality Segment

100

color

colorless

solubility

DMSO: soluble

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@]12CCCCCC[C@@]3([H])CCCN4CC[C@@]([H])(CCCCCC[C@]5([H])CCCN(CC1)[C@@]5([H])O2)O[C@@]34[H]

InChI

1S/C28H50N2O2/c1-3-7-15-25-17-21-30-20-10-14-24(28(30)31-25)12-6-2-4-8-16-26-18-22-29-19-9-13-23(11-5-1)27(29)32-26/h23-28H,1-22H2/t23-,24+,25-,26-,27+,28+/m1/s1

InChI key

PQYOPBRFUUEHRC-HCKQMYSWSA-N

Description

General description

Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge.

Biochem/physiol Actions

Xestospongin C is a potent, reversible and membrane-permeable blocker of IP₃-mediated Ca²⁺release (IC₅₀=358 nM).

Xestospongin C is a selective, reversible and membrane-permeable inhibitor of IP₃ receptor. Reversibly blocks bradykinin- and carbamylcholine- Ca²⁺ efflux from the endoplasmic reticulum stores.

Features and Benefits

This compound is featured on the InsP3/Ryanodine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Packaging

Package under nitrogen, tightly sealed.

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1 of 1

This Item	682160-M	C5552	574776
Sigma-Aldrich X2628 Xestospongin C	Millipore 682160-M Xestospongin C, Xestospongia sp.	Sigma-Aldrich C5552 Calyculin A from Discodermia calyx	Sigma-Aldrich 574776 Swinholide A, Theonella swinhoei
form film	form film	form solid	form oil
Quality Level 100	Quality Level 100	Quality Level 200	Quality Level 100
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
solubility DMSO: soluble	solubility DMSO: 1 mg/mL, ethanol: 1 mg/mL, methanol: 1 mg/mL	solubility DMSO: soluble, ethanol: soluble	solubility acetone: soluble, ethanol: soluble
color colorless	color white to off-white	color white	color colorless
shipped in dry ice	shipped in -	shipped in -	shipped in ambient

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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