SML3740

PY-60

≥98% (HPLC), YAP1 signaling activator, powder

• Synonym(s): 5-Phenyl-N-[3-(2-thiazolyl)propyl]-3-isoxazolecarboxamide
• Empirical Formula (Hill Notation): C₁₆H₁₅N₃O₂S
• CAS Number: 2765218-56-0
• Molecular Weight: 313.37
• UNSPSC Code: 12352200
• NACRES: NA.21
• MDL number: MFCD34474253
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Product Name: PY-60, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C

Description

Biochem/physiol Actions

PY-60 is a potent and specific activator of the transcriptional coactivator Yes-associated protein 1 (YAP) signaling. It stimulates YAP-dependent expansion of epidermal keratinocytes in mouse. PY-60 binds directly to annexin A2 (ANXA2) causing its liberation and YAP activation.

potent and specific activator YAP that binds directly to annexin A2.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable