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SML3028

Apostatin-1

≥98% (HPLC)

Synonym(s):

N-Cycloheptyl-?-[(4,5-dihydro-1-methyl-1H-imidazol-2-yl)thio]-benzeneacetamide

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About This Item

Empirical Formula (Hill Notation):
C19H27N3OS
CAS Number:
2559703-06-7
Molecular Weight:
345.50
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(C(C1=CC=CC=C1)SC2=NCCN2C)NC3CCCCCC3

InChI key

OXBMBNASDMMXSA-UHFFFAOYSA-N

Biochem/physiol Actions

Apostatin-1 is a cell penetrant apoptosis inhibitor that activates autophagy leading to restoration of cellular homeostasis in cells with accumulated mutant tau, α-synuclein, or huntingtin. Apostatin-1 potently and selectively inhibits TRADD. It binds to the N-terminal TRAF2-binding domain of TRADD (TRADD-N). Apparently Apostatin-1 releases cIAP1/2 or TRAF2 from TRADD thus promoting the K63-linked ubiquitination of beclin 1.
cell penetrant apoptosis inhibitor that activates autophagy that potently and selectively inhibits TRADD

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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