SML1485

SW033291

≥98% (HPLC)

• Synonym(s): 2-(Butane-1-sulfinyl)-4-phenyl-6-thiophen-2-yl-thieno[2,3-b]pyridin-3-ylamine
• Empirical Formula (Hill Notation): C₂₁H₂₀N₂OS₃
• CAS Number: 459147-39-8
• Molecular Weight: 412.59
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825914
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: light yellow to yellow-green
• solubility: DMSO: 5 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• SMILES string: NC1=C(S(CCCC)=O)SC2=NC(C3=CC=CS3)=CC(C4=CC=CC=C4)=C21
• InChI: 1S/C21H20N2OS3/c1-2-3-12-27(24)21-19(22)18-15(14-8-5-4-6-9-14)13-16(23-20(18)26-21)17-10-7-11-25-17/h4-11,13H,2-3,12,22H2,1H3
• InChI key: LCYAYKSMOVLVRL-UHFFFAOYSA-N

Description

Biochem/physiol Actions

SW033291 is an inhibitor of the prostaglandin-degrading enzyme 15-PGDH. PGE2 is known to promote hematopoiesis and to promote reeneration by causing stem cells to proliferate. 15-PGDH degrades prostaglandin PGE2 and is a negative regulator of tissue regeneration and repair. SW033291 inhibition of 15-PGDH doubled levels of PGE2 and doubled rates of colon and liver tissue regeneration. Mice given SW033291 after receiving a bone marrow transplant had a two- to threefold increase in the number of donor cells that homed to the their bone marrow.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable