SCP0152

Gastrin I (1-14)

≥92% (HPLC)

• Empirical Formula (Hill Notation): C₇₉H₁₀₀N₁₆O₂₇
• Molecular Weight: 1705.73
• NACRES: NA.32
• UNSPSC Code: 51111800

Properties

• assay: ≥92% (HPLC)
• form: lyophilized
• composition: Peptide Content, ≥75%
• storage condition: protect from light
• storage temp.: −20°C

Description

General description

Gastrin, a classic digestive hormone, is found in three major forms: gastrin-34 (big gastrin), gastrin-17 (little gastrin), and gastrin-13 (minigastrin). Mammalian gastrin consists of a C-terminal four amino-acid sequence and a sulfated tyrosine 7 residue from the C-terminus. Gastrin is mostly found in the G cells of the stomach mucosa. Nutrients and gastrin-releasing peptides stimulate the release of gastrin.

Application

Gastrin I (1-14) has been used:

• as a component of gastric cancer stem/progenitor cell (GCSPC) medium for tumorsphere culture
• as a supplement in organoid growth medium (OGM) for patient-derived organoid (PDO)
• in viable lymphocytes culture for re-stimulation assay

Biochem/physiol Actions

The peptide gastrin I (1-14), which lacks a basic site, forms positive ions. Gastrin promotes the production and liberation of histamine in enterochromaffin-like cells through cholecystokinin 2 receptor (CCK2R). It also stimulates the release of gastric acid in parietal cells via the CCK2R receptor. Gastrin plays a key role in Zollinger-Ellison syndrome. It may play a role in the development of colorectal carcinoma.

Gastrin is a linear polypeptide that induces the secretion of gastric acid (HCl) by parietal cells.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable