Melanoma-associated antigen 1 (MAGE-A1) belongs to the melanoma-associated antigen (MAGE) gene family. It is also termed cancer-testis antigen (CTA) or cancer-germline (CG) gene. The MAGE-A1 gene is mostly expressed in the human germline. It is also expressed in the placenta and various tumor cells. MAGE-A1 gene is located on human chromosome Xq28.
Immunogen
Synthetic peptide derived from the C-terminus of human MAGE-A1 protein.
Biochem/physiol Actions
Melanoma-associated antigen 1 (MAGE-A1) stimulates the proliferation and colony formation of melanoma cells. It might modulate the oncogenic C-JUN expression either directly or via the extracellular-signal-regulated kinase (ERK)-mitogen-activated protein kinase (MAPK) signaling pathway. Hence, MAGE-A1 could be a possible therapeutic target for patients with melanoma. It can be a potential marker in the treatment of lung adenocarcinoma (LUAD).
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Physical form
0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
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Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Biochemical and biophysical research communications, 473(4), 959-965 (2016-04-06)
MAGE-A1 belongs to the chromosome X-clustered genes of cancer-testis antigen family and is normally expressed in the human germ line but is also overexpressed in various tumors. Previous studies of MAGE-A1 in melanoma mainly focused on methylation changes or its
Journal of hematology & oncology, 12(1), 106-106 (2019-10-24)
Cancer/testis antigens (CTAs) are a special type of tumor antigen and are believed to act as potential targets for cancer immunotherapy. In this study, we first screened a rational CTA MAGE-A1 for lung adenocarcinoma (LUAD) and explored the detailed characteristics
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