L7134

Luteinizing hormone releasing hormone human acetate salt

≥98% (HPLC), powder

• Synonym(s): Gonadoliberin, Gonadotropin releasing hormone, LH-RH
• Empirical Formula (Hill Notation): C₅₅H₇₅N₁₇O₁₃
• CAS Number: 71447-49-9
• Molecular Weight: 1182.29
• NACRES: NA.32
• PubChem Substance ID: 329817648
• UNSPSC Code: 51111800
• MDL number: MFCD00133489

Properties

• Quality Segment: 200
• assay: ≥98% (HPLC)
• form: powder
• mol wt: M_r 1182.33
• UniProt accession no.: P01148
• storage temp.: −20°C
• SMILES string: CC(O)=O.CC(O)=O.CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc4c[nH]cn4)NC(=O)[C@@H]5CCC(=O)N5)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N6CCC[C@H]6C(=O)NCC(N)=O
• InChI: 1S/C55H75N17O13.2C2H4O2/c1-29(2)19-38(49(80)67-37(9-5-17-60-55(57)58)54(85)72-18-6-10-43(72)53(84)62-25-44(56)75)66-46(77)26-63-47(78)39(20-30-11-13-33(74)14-12-30)68-52(83)42(27-73)71-50(81)40(21-31-23-61-35-8-4-3-7-34(31)35)69-51(82)41(22-32-24-59-28-64-32)70-48(79)36-15-16-45(76)65-36;2*1-2(3)4/h3-4,7-8,11-14,23-24,28-29,36-43,61,73-74H,5-6,9-10,15-22,25-27H2,1-2H3,(H2,56,75)(H,59,64)(H,62,84)(H,63,78)(H,65,76)(H,66,77)(H,67,80)(H,68,83)(H,69,82)(H,70,79)(H,71,81)(H4,57,58,60);2*1H3,(H,3,4)/t36-,37-,38-,39-,40-,41-,42-,43-;;/m0../s1
• InChI key: QOVPLTBEZAJSHY-VIRDRFNDSA-N
• Gene Information: human ... GNRH1(2796)

Description

Application

Luteinizing hormone releasing hormone human acetate salt has been used:

• for synchronization of the ovulations
• for pre-absorption of the anti-GnRH antibody in staining procedures
• to study pituitary sensitivity to GnRH in presence of endocrine disrupting compound

Biochem/physiol Actions

Hypothalamic peptide that stimulates release of gonadotrophins from anterior pituitary, thus regulating reproductive functions.

Stimulates release of gonadotrophins from anterior pituitary.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Lyophilized from 0.5% acetic acid

free peptide

pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂

Safety Information

• pictograms: GHS08
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
• target_organs: Endocrine system
• signalword: Warning
• hcodes: H361fd,H373
• pcodes: P202 - P260 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 2 - STOT RE 2
• Storage Class: 11 - Combustible Solids