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Dichloromethane

Name: Dichloromethane
Brand: SIGMA

Synonym(s):

Methylene chloride

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About This Item

Linear Formula:

CH₂Cl₂

CAS Number:

75-09-2

Molecular Weight:

84.93

UNSPSC Code:

12352101

NACRES:

NA.21

PubChem Substance ID:

329817376

EC Number:

200-838-9

Beilstein/REAXYS Number:

1730800

MDL number:

MFCD00000881

Technique(s):

DNA synthesis: suitable

Bp:

39.8-40 °C (lit.)

Vapor pressure:

24.45 psi ( 55 °C), 6.83 psi ( 20 °C)

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Properties

vapor density

2.9 (vs air)

Quality Segment

200

vapor pressure

24.45 psi ( 55 °C), 6.83 psi ( 20 °C)

type

for DNA synthesis

product line

Proligo Reagents

form

liquid

autoignition temp.

1223 °F

contains

amylene as stabilizer

expl. lim.

22 %

storage condition

dry at room temperature

technique(s)

DNA synthesis: suitable

impurities

≤50 ppm water content (Karl Fischer)

color

clear

refractive index

n/D 1.421-1.425, n20/D 1.424 (lit.)

bp

39.8-40 °C (lit.)

mp

−95 °C (lit.)

density

1.325 g/mL at 25 °C (lit.)

SMILES string

ClCCl

InChI

1S/CH2Cl2/c2-1-3/h1H2

InChI key

YMWUJEATGCHHMB-UHFFFAOYSA-N

Description

General description

In the solid-phase synthesis of oligonucleotides, liquid reagents are used in each step of the synthesis cycle. Overall synthesis performance, and therefore total product yield and purity of the crude oligonucleotide, is highly dependent on the chemical purity of the monomers and the supporting liquid reagents and other solvents like ethylacetate, dichloromethane, and dimethylformadine .Dichloromethane is an ordinary organic solvent frequently utilized in peptide synthesis. Under normal circumstances, DCM maintains highly stable and will not cause significant side reactions in peptide synthesis. It is a chlorinated organic solvent that is susceptible to degradation with time. This can be suppressed by adding amylene as a stabilizer.Dichloromethane has been tested as a solvent medium for the dipyridine-chromium(VI) oxide. Solubility was reported to be 12.5g/100ml. The role of the quantity of TiO2 loading on activated carbon support employed in the photodecomposition of dichloromethane has been investigated.

Application

Dichloromethane may be used as a solvent for the preparation of stock solutions of carotenoids. It may be employed as a solvent in the synthesis of polylactide-based (PLA) thin films. IT is also suitable as a solvent for the oxidation of primary and secondary alcohols using dipyridine-chromium(VI) oxide.

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This Item	DX0831	DX0830	91301
Sigma-Aldrich L090000 Dichloromethane	Supelco DX0831 Dichloromethane	Supelco DX0830 Dichloromethane	Supelco 91301 Dichloromethane
description -	description OmniSolv^®	description Biosynthesis OmniSolv^®	description Selectophore^™, ≥99.5% (GC), inhibitor-free
technique(s) DNA synthesis: suitable	technique(s) gas chromatography (GC): suitable, HPLC: suitable, LC/MS: suitable	technique(s) -	technique(s) GC/GC: suitable
Quality Level 200	Quality Level 100	Quality Level 200	Quality Level 200
form liquid	form liquid	form liquid	form liquid
bp 39.8-40 °C (lit.)	bp 39.8-40 °C (lit.)	bp 39.8-40 °C (lit.)	bp 39.8-40 °C (lit.)
impurities ≤50 ppm water content (Karl Fischer)	impurities ≤2 ng/L Capillary ECD responsive substances (as PCNB), ≤3 μg/L Capillary FID responsive substances (as decane), ≤0.005% Water (H₂O), ≤0.2 μeq/g Titrable acid	impurities ≤30 ppm Water (H₂O), ≤1 ppm Halogen (as Cl), ≤0.3 μeq/g Titrable acid	impurities ≤0.02% water
mp −95 °C (lit.)	mp −95 °C (lit.), -95 °C	mp -95 °C, −95 °C (lit.)	mp −95 °C (lit.)

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Pictograms

GHS08,GHS07

Signal Word

Warning

Hazard Codes

H315,H319,H336,H351

Precautionary Statements

P202 - P261 - P264 - P302 + P352 - P305 + P351 + P338 - P308 + P313

Hazard Classifications

Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Central nervous system

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 2

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