I4765
Human IgG4 Lambda, Recombinant Protein
purified immunoglobulin
Synonym(s):
Human IgG4 Protein
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
human (recombinant)
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
shipped in
dry ice
storage temp.
−20°C
General description
IgG antibody subtype is the most abundant serum immunoglobulins of the immune system. It is secreted by B cells and is found in blood and extracellular fluids and provides protection from infections caused by bacteria, fungi and viruses. Maternal IgG is transferred to fetus through the placenta that is vital for immune defense of the neonate against infections. IgG4 is the least abundant of the IgG subclass. IgG4-related systemic diseases include autoimmune pancreatitis, mediastinal fibrosis and multiple sclerosis.
IgG4, λ recombinant protein is obtained by expression of a phage library in a human cell line and purified by affinity chromatography.
IgG4, λ recombinant protein is obtained by expression of a phage library in a human cell line and purified by affinity chromatography.
Application
The purified IgG4, λ may be used as an immunoglobulin calibrator, reference antigen, blocking agent, or coating protein in a variety of immunoassays including ELISA, dot blot immunobinding, Western immunobloting, immunodiffusion, immunoelectrophoresis, hemagglutination, and cell binding assays. Purified IgG4, λ was used as isotype control in flow cytometry of chronic lymphocytic leukemia and mantle cell lymphoma cells. It was also used for lectin- surface plasmon resonance and IgG subclass labelling by flow cytometry at a concentration of 50 μg/mL.
Analysis Note
The purity and identity are determined by immunoelectrophoresis, indirect ELISA, and SDS-PAGE.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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