G7048

Proguanil hydrochloride

≥95% (HPLC)

• Synonym(s): Chlorguanide, N¹-(4-Chlorophenyl)-N⁵-isopropylbiguanide
• Empirical Formula (Hill Notation): C₁₁H₁₆ClN₅·HCl
• CAS Number: 637-32-1
• Molecular Weight: 290.19
• NACRES: NA.77
• PubChem Substance ID: 329799959
• UNSPSC Code: 51101906
• EC Number: 211-283-7
• MDL number: MFCD01732193
• Assay: ≥95% (HPLC)
• Form: solid
• Storage condition: desiccated

Properties

• assay: ≥95% (HPLC)
• form: solid
• storage condition: desiccated
• solubility: acetonitrile: water: ~1 mg/mL (60/40)
• originator: AstraZeneca
• storage temp.: 2-8°C
• SMILES string: Cl.CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1
• InChI: 1S/C11H16ClN5.ClH/c1-7(2)15-10(13)17-11(14)16-9-5-3-8(12)4-6-9;/h3-7H,1-2H3,(H5,13,14,15,16,17);1H
• InChI key: SARMGXPVOFNNNG-UHFFFAOYSA-N

Description

Application

Proguanil (chlorguanide) may be used in anti-parasitic protozoan drug development to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as an antimalarial drug.

Biochem/physiol Actions

Chlorguanide (proguanil) is combined with atovaquone for malaria prophylaxis. The two compounds act synergistically to inhibit the plasmodial dihydrofolate reductase (DHFR) and interrupt the electron transport chain. Mutations in DHFR account for the development of resistant strains.

Proguanil hydrochloride is antimalarial. Dihydrofolate reductase inhibitor

Features and Benefits

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable