G0923

Golgicide A

≥98% (HPLC)

• Synonym(s): 6,8-Difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline, CID 25113626, GCA
• Empirical Formula (Hill Notation): C₁₇H₁₄F₂N₂
• CAS Number: 1005036-73-6
• Molecular Weight: 284.30
• MDL number: MFCD27937048
• UNSPSC Code: 12352200
• PubChem Substance ID: 329799717
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: solid

Properties

• assay: ≥98% (HPLC)
• form: solid
• solubility: DMSO: >10 mg/mL
• storage temp.: room temp
• SMILES string: Fc1cc(F)c2NC([C@@H]3CC=C[C@@H]3c2c1)c4cccnc4
• InChI: 1S/C17H14F2N2/c18-11-7-14-12-4-1-5-13(12)16(10-3-2-6-20-9-10)21-17(14)15(19)8-11/h1-4,6-9,12-13,16,21H,5H2/t12-,13+,16?/m0/s1
• InChI key: NJZHEQOUHLZCOX-FTLRAWMYSA-N

Description

Application

Golgicide A has been used as an inhibitor in retrotransposition assays and as an inhibitor of Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 protein (GBF1) in HeLa cells.

Biochem/physiol Actions

Golgicide A is a potent, highly specific, reversible inhibitor of the cis-Golgi ArfGEF GBF1.

Golgicide A is a potent, highly specific, reversible inhibitor of the cis-Golgi ArfGEF GBF1. Arf proteins are members of the Ras superfamily of small guanosine triphosphatases (GTPases) that mediate vesicular transport. Golgicide A binds within an interfacial cleft formed between Arf1 and the GBF1 Sec7 domain. Golgicide A is a unique and powerful tool for further elucidating the mechanisms underlying assembly and transport within the Golgi, comparable to the use of dynasore for studying the dynamics of dynamin-mediated clathrin coat formation.

Features and Benefits

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Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H319
• pcodes: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable