8.02540

Cobalt(II) chloride anhydrous

for synthesis

• Synonym(s): Cobalt(II) chloride anhydrous, Cobalt dichloride
• Empirical Formula (Hill Notation): Cl₂Co
• CAS Number: 7646-79-9
• Molecular Weight: 129.84
• UNSPSC Code: 12352302
• EC Index Number: 231-589-4
• NACRES: NA.22
• MDL number: MFCD00010938

Properties

• grade: anhydrous
• Quality Segment: 200
• form: powder
• potency: 418 mg/kg LD₅₀, oral (Rat)
• mp: 735 °C
• solubility: soluble 585.9 g/L
• density: 3.36 g/cm³ at 25 °C
• storage temp.: 2-30°C
• SMILES string: [Co+2].[Cl-].[Cl-]
• InChI: 1S/2ClH.Co/h2*1H;/q;;+2/p-2
• InChI key: GVPFVAHMJGGAJG-UHFFFAOYSA-L

Description

Application

Cobalt(II) chloride anhydrous (CoCl₂) can be used as a catalyst in organic synthesis for the transformation of the various functional groups. For example, synthesis of esters via cleavage of ethers by acyl chlorides; acylation of alcohols and amines by anhydrides; and regioselective cleavage of oxiranes. It is also used to synthesize mixed acetals by the addition reaction between alcohols and vinyl ethers.
CoCl₂ can be used as a catalyst:

• For the dealkylation of tertiary amines.
• In the synthesis of thioketones and thioaldehydes via thionation of carbonyl compounds in the presence of bis(trimethylsilyl) sulfide.
• In the oxidation of aromatic and aliphatic aldehydes to carboxylic acids in the presence of molecular oxygen and acetic anhydride.
• In the stereoselective opening of epoxides with N-substituted anilines.

CoCl₂ can also be used as:

• A precursor to synthesize magnetic cobalt nanorods via decomposition of the cobalt coordination complex.
• A catalyst to prepare acid anhydrides by the reaction of acid chlorides with carboxylic acids.
• A reagent in the carbon-carbon bond-forming reactions involving active methylene compounds.

Analysis Note

Assay (argentometric): ≥ 98.0 %
Water (K. F.): ≤ 2.0 %

Safety Information

• signalword: Danger
• pcodes: P273 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B Inhalation - Eye Dam. 1 - Muta. 2 - Repr. 1B - Resp. Sens. 1 - Skin Sens. 1
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• pictograms: GHS08,GHS05,GHS07,GHS09
• hcodes: H302,H317,H318,H334,H341,H350i,H360F,H410
• Storage Class: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects