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662056

Sigma-Aldrich

Ubiquitin Aldehyde

≥95% (HPLC), liquid, ubiquitin hydrolase inhibitor, Calbiochem®

Synonym(s):

ubiquitin hydrolase inhibitor

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.77

product name

Ubiquitin Aldehyde, Potent and specific inhibitor of multiple ubiquitin hydrolases involved in pathways of intracellular protein modification and turnover.

Quality Level

100

Assay

≥95% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

solubility

DMSO: 50 mg/mL
aqueous buffer: soluble

shipped in

ambient

storage temp.

−20°C

General description

Potent and specific inhibitor of multiple ubiquitin hydrolases involved in pathways of intracellular protein modification and turnover. Useful for stabilizing endogenous or in vitro synthesized ubiquitin-protein conjugates. May also be used to enhance or decrease rates of ubiquitin-dependent degradation.
Potent and specific inhibitor of multiple ubiquitin hydrolases involved in pathways of intracellular protein modification and turnover. Useful for stabilizing endogenous or in vitro synthesized ubiquitin-protein conjugates. May also be used to enhance or decrease the rates of ubiquitin-dependent degradation.

Biochem/physiol Actions

Cell permeable: no
Primary Target
multiple ubiquitin hydrolases involved in pathways of intracellular protein modification and turnover
Product does not compete with ATP.
Reversible: no
Shown to inhibit the activity of Isopeptidase T (Cat. No. 419700) and Ubiquitin C-Terminal Hydrolase (Cat. No. 662090)

Packaging

Please refer to vial label for lot-specific concentration.

Warning

Toxicity: Standard Handling (A)

Physical form

In 150 mM HCL.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C).

Other Notes

Melandri, F., et al. 1996. Biochemistry 35, 12893.
Shaeffer, J.R. and Cohen, R.E. 1996. Biochemistry 35, 10886.
Pickart, C.M. and Rose, I.A. 1986. J. Biol. Chem. 261, 10210.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Mengmeng Niu et al.
PLoS biology, 19(2), e3001113-e3001113 (2021-02-25)
Transforming growth factor-β (TGF-β) signaling plays a critical role in promoting epithelial-to-mesenchymal transition (EMT), cell migration, invasion, and tumor metastasis. ΔNp63α, the major isoform of p63 protein expressed in epithelial cells, is a key transcriptional regulator of cell adhesion program
Mengmeng Niu et al.
Nature communications, 12(1), 5919-5919 (2021-10-13)
Abnormal activation of epidermal growth factor receptor (EGFR) drives non-small cell lung cancer (NSCLC) development. EGFR mutations-mediated resistance to tyrosine-kinase inhibitors (TKIs) is a major hurdle for NSCLC treatment. Here, we show that F-box protein FBXL2 targets EGFR and EGFR

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