495414

1-Oleoyl-2-acetyl-sn-glycerol

Cell-permeable diacylglycerol analog that activates Ca²⁺-dependent protein kinase C.

• Synonym(s): 1-Oleoyl-2-acetyl-sn-glycerol, OAG, PKC Activator III
• Empirical Formula (Hill Notation): C₂₃H₄₂O₅
• CAS Number: 86390-77-4
• Molecular Weight: 398.58
• MDL number: MFCD00166985
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥97% (HPLC)
• form: oil
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• solubility: DMSO: soluble; ethanol: soluble
• format: neat
• shipped in: ambient
• storage temp.: −20°C
• InChI: 1S/C23H42O5/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)27-20-22(19-24)28-21(2)25/h10-11,22,24H,3-9,12-20H2,1-2H3/b11-10-/t22-/m0/s1
• InChI key: PWTCCMJTPHCGMS-YRBAHSOBSA-N

Description

General description

Cell-permeable diacylglycerol analog that activates Ca²⁺-dependent protein kinase C. Also a stimulator of secretion and aggregation in blood platelets.

Note: 1 set = 10 x 500 µg.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Ca2+-dependent protein kinase C

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Standard Handling (A)

Reconstitution

Unstable in solution; reconstitute just prior to use. The material can be dissolved in chloroform, aliquoted, dried under a stream of nitrogen, and stored at -20°C.

Other Notes

Florin-Christensen, J. 1993. Biochem. J.289, 783.
Benz, I., et al. 1992. J. Membr. Biol. 130, 183.
Haeffner, E.W., and Wittmann, U. 1992. J. Lipid Mediat.5, 237.
Gilmore, T., and Martin, G.S. 1983. Nature306, 487.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable