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Key Documents

07-788

Sigma-Aldrich

Anti-phospho-Abl (Tyr412) Antibody

Upstate®, from rabbit

Synonym(s):

ABL1, JTK7, c-ABL, p150, v-abl, v-abl Abelson murine leukemia viral oncogene homolog 1

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human, mouse, rat

manufacturer/tradename

Upstate®

technique(s)

ELISA: suitable
western blot: suitable

isotype

IgG

NCBI accession no.

NM_005157.3
NM_007313.2

UniProt accession no.

P00519

shipped in

dry ice

target post-translational modification

phosphorylation (pTyr412)

Gene Information

human ... ABI1(10006)
mouse ... Abi1(11308)
rat ... Abi1(79249)

Specificity

Other species have not been tested.
Recognizes both Abl and BCR-Abl when phosphorylated on tyrosine residue corresponding to Tyr412 in Abl.

Immunogen

KLH-conjugated peptide corresponding to amino acid region encompassing human c-Abl Tyr412.

Application

Research Category
Signaling
Research Sub Category
Cytoskeletal Signaling

General Post-translation Modification
This Anti-phospho-Abl (Tyr412) Antibody is validated for use in ELISA, WB for the detection of phospho-Abl (Tyr412).

Quality

Routinely evaluated by immunoblot.

Target description

145 kDa

Physical form

ImmunoAffinity Purified

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Phosphotyrosine mapping in Bcr/Abl oncoprotein using phosphotyrosine-specific immonium ion scanning
Steen, Hanno, et al
Molecular and Cellular Proteomics, 2, 138-145 (2003)
Wenjing Tao et al.
The Journal of biological chemistry, 289(31), 21463-21472 (2014-06-14)
Jak2 is involved in cytokine growth factor-stimulated signal transduction, but the mechanism of its activation is largely unknown. Here, we investigated Jak2 activation in a normal hematopoietic cell line, 32D mouse myeloid cells. The bimolecular fluorescence complementation studies showed that
Phosphoproteomic analysis of AML cell lines identifies leukemic oncogenes
Walters, Denise K, et al
Leukemia Research, 30, 1097-1104 (2006)
Jia Hu et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 30(2), 450-461 (2023-11-09)
This study sought to identify β-catenin targets that regulate desmoid oncogenesis and determine whether external signaling pathways, particularly those inhibited by sorafenib (e.g., PDGFRβ), affect these targets to alter natural history or treatment response in patients. In vitro experiments utilized
Tamara Marín et al.
Frontiers in cell and developmental biology, 10, 844297-844297 (2022-04-12)
Niemann-Pick type A (NPA) disease is a fatal lysosomal neurodegenerative disorder caused by the deficiency in acid sphingomyelinase (ASM) activity. NPA patients present severe and progressive neurodegeneration starting at an early age. Currently, there is no effective treatment for this
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