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D1133

Sigma-Aldrich

Diethylenetriaminepentaacetic acid

≥98% (titration)

Synonym(s):

(Carboxymethylimino)bis(ethylenenitrilo)tetraacetic acid, N,N-Bis(2-[bis(carboxymethyl)amino]ethyl)glycine, DETAPAC, DTPA, Penta(carboxymethyl)diethylenetriamine, Pentetic acid

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About This Item

Linear Formula:
[(HOOCCH2)2NCH2CH2]2NCH2COOH
CAS Number:
Molecular Weight:
393.35
Beilstein:
1810219
EC Number:
MDL number:
UNSPSC Code:
12352201
PubChem Substance ID:
NACRES:
NA.21
Pricing and availability is not currently available.

biological source

synthetic (organic)

Quality Level

Assay

≥98% (titration)

form

powder

mp

219-220 °C (lit.)

solubility

1 M HCl: 50 mg/mL, clear, colorless

storage temp.

room temp

SMILES string

OC(=O)CN(CCN(CC(O)=O)CC(O)=O)CCN(CC(O)=O)CC(O)=O

InChI

1S/C14H23N3O10/c18-10(19)5-15(1-3-16(6-11(20)21)7-12(22)23)2-4-17(8-13(24)25)9-14(26)27/h1-9H2,(H,18,19)(H,20,21)(H,22,23)(H,24,25)(H,26,27)

InChI key

QPCDCPDFJACHGM-UHFFFAOYSA-N

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Application

Diethylenetriaminepentaacetic acid may be used to synthesize chitosan (CH)-gadolinium (Gd) diethylenetriaminepentaacetic acid (DTPA) conjugates.[1]

Pictograms

Health hazardExclamation mark

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 4 Inhalation - Eye Irrit. 2 - Repr. 1B - STOT RE 2 Inhalation

Target Organs

Respiratory Tract

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

Flash Point(F)

392.0 °F - closed cup

Flash Point(C)

200 °C - closed cup


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Chitosan modified with gadolinium diethylenetriaminepentaacetic acid for magnetic resonance imaging of DNA/chitosan nanoparticles.
Darras V, et al.
Carbohydrate Polymers, 80(4), 1137-1146 (2010)
Gauthier J-P Deblonde et al.
Nature communications, 10(1), 2438-2438 (2019-06-06)
Metal ion separations are critical to numerous fields, including nuclear medicine, waste recycling, space exploration, and fundamental research. Nonetheless, operational conditions and performance are limited, imposing compromises between recovery, purity, and cost. Siderophore-inspired ligands show unprecedented charge-based selectivity and compatibility
P C Adams et al.
Hepatology (Baltimore, Md.), 14(6), 1230-1234 (1991-12-01)
The elimination of toxic metal ions metabolically accumulated by patients remains a difficult clinical problem and a target of drug development. DTPA (diethylenetriaminepentaacetic acid) is a hydrophilic chelating agent with high affinity for divalent and trivalent metal ions including iron
Maria P Sciaudone et al.
Biological trace element research, 99(1-3), 219-231 (2004-07-06)
Zinc is thought to be required as a structural component of the thyroid hormone (triiodothyronine, T3) receptor (TR). However, we have previously demonstrated that use of diethylenetriaminepentaacetic acid (DTPA) to restrict zinc availability to cultured cells actually potentiates rather than
Kosmas Vamvakidis et al.
Materials (Basel, Switzerland), 13(7) (2020-04-02)
Water pollution by heavy metals is one of the most serious worldwide environmental issues. With a focus on copper(II) ions and copper complex removal, in the present study, ultra-small primary CoFe2O4 magnetic nanoparticles (MNPs) coated with octadecylamine (ODA) of adequate

Questions

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  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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