201170

Phosphorus(V) oxychloride

ReagentPlus^®, 99%

• Synonym(s): Phosphorus(V) oxide chloride, Phosphoryl chloride
• Linear Formula: POCl₃
• CAS Number: 10025-87-3
• Molecular Weight: 153.33
• NACRES: NA.22
• PubChem Substance ID: 57647818
• UNSPSC Code: 12352101
• EC Number: 233-046-7
• MDL number: MFCD00011443
• Assay: 99%
• Bp: 105.8 °C (lit.)
• Vapor pressure: 104 mmHg ( 50 °C), 28 mmHg ( 20 °C)

Properties

• Quality Segment: 200
• vapor density: 5.3 (vs air)
• vapor pressure: 104 mmHg ( 50 °C), 28 mmHg ( 20 °C)
• product line: ReagentPlus^®
• assay: 99%
• form: liquid
• reaction suitability: reaction type: Halogenations
• dilution: (for general lab use)
• pH: 1 (20 °C)
• bp: 105.8 °C (lit.)
• mp: 1.25 °C (lit.)
• density: 1.645 g/mL at 25 °C (lit.)
• functional group: phosphine oxide
• SMILES string: ClP(Cl)(Cl)=O
• InChI: 1S/Cl3OP/c1-5(2,3)4
• InChI key: XHXFXVLFKHQFAL-UHFFFAOYSA-N

Description

Application

Phosphorus(V) oxychloride (POCl₃) is a chlorinating agent that reacts with dimethylformamide (DMF) to form Vilsmeier reagent for Vilsmeier-Haack formylation reactions.
It can also be used as a reagent in the synthesis of:

• Quinazolin-4(3H)-one derivatives from 2-aminobenzamides via in situ preparation of Vilsmeier reagent.
• Substituted 1-arylseleno-4-halo-2-enes by treating conjugated dienes with arylselenenamides.
• 3-methylthioimidazo[1,2-a]pyridines and imidazo-fused heterocycles in the presence of DMSO.

Packaging

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Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS06,GHS08,GHS05
• Signal Word: Danger
• Hazard Codes: H302,H314,H330,H372
• Precautionary Statements: P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P314
• Hazard Classifications: Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1A - STOT RE 1 Inhalation
• Target Organs: Respiratory Tract
• supp_hazards: EUH014,EUH029
• Storage Class: 6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter