142859

Difluoroacetic acid

98%

• Synonym(s): 1,1-Difluoroacetic acid, 2,2-Difluoroacetic acid
• Linear Formula: F₂CHCO₂H
• CAS Number: 381-73-7
• Molecular Weight: 96.03
• Beilstein: 1098588
• EC Number: 206-839-0
• MDL number: MFCD00004220
• UNSPSC Code: 12352106
• PubChem Substance ID: 24848539
• NACRES: NA.22

Properties

• Assay: 98%
• form: liquid
• refractive index: n20/D 1.344 (lit.)
• bp: 132-134 °C (lit.)
• mp: −1 °C (lit.)
• density: 1.526 g/mL at 25 °C (lit.)
• SMILES string: OC(=O)C(F)F
• InChI: 1S/C2H2F2O2/c3-1(4)2(5)6/h1H,(H,5,6)
• InChI key: PBWZKZYHONABLN-UHFFFAOYSA-N

Description

General description

Difluoroaceticacid is a monocarboxylic acid and an organofluorine compound. Difluoroaceticacid is easy-to-handle reagent, useful for obtaining difluoromethyl substituents. Difluoroacetic acid can be used asdifluoromethylating reagent for the direct C−H difluoromethylation ofheteroaromatic compounds.

Application

Used in the preparation of 2-difluoromethylbenzimidazoles, -oxazoles and -thiazoles from ortho-substituted anilines mediated by triphenylphoshine.

Safety Information

• Pictograms: GHS05,GHS07
• Signal Word: Danger
• Hazard Statements: H314,H332,H412
• Precautionary Statements: P261 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Inhalation - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1A
• Storage Class Code: 8A - Combustible corrosive hazardous materials
• WGK: WGK 3
• Flash Point(F): 172.4 °F - closed cup
• Flash Point(C): 78 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves