8.22299

Piperidine

for synthesis

• Synonym(s): Piperidine, Hexahydropyridine, Pentamethyleneimine, Azacyclohexane, Azinane
• Empirical Formula (Hill Notation): C₅H₁₁N
• CAS Number: 110-89-4
• Molecular Weight: 85.15
• MDL number: MFCD00005979
• UNSPSC Code: 12352005
• EC Index Number: 203-813-0
• NACRES: NA.22
• Assay: ≥99% (GC)
• bp: 106 °C/1013 hPa
• vapor pressure: 34 hPa ( 20 °C)

Properties

• vapor pressure: 34 hPa ( 20 °C)
• Quality Level: 200
• Assay: ≥99% (GC)
• form: liquid
• autoignition temp.: 320 °C
• potency: 276 mg/kg LD₅₀, skin (Rabbit)
• expl. lim.: 1.5-10.3 % (v/v)
• pH: 12.6 (20 °C, 100 g/L in H₂O)
• kinematic viscosity: 1.77 cSt(20 °C)
• bp: 106 °C/1013 hPa
• mp: -10.8 °C
• transition temp: flash point 16 °C
• density: 0.86 g/cm³ at 20 °C
• storage temp.: 2-30°C
• SMILES string: N1CCCCC1
• InChI: 1S/C5H11N/c1-2-4-6-5-3-1/h6H,1-5H2
• InChI key: NQRYJNQNLNOLGT-UHFFFAOYSA-N

Description

General description

Piperidine is a heterocyclic amine with a six-membered ring containing five methylene bridges (-CH₂-) and one amine bridge (-NH-). Numerous alkaloids, pharmaceuticals, agrochemicals, and synthetic and biological intermediates contain the piperidine moiety. The commercial applications of piperidine include: solvent for curing agents and epoxy resins. In organic synthesis, it serves as an intermediate.

Application

Piperidine is used:

• As an organic structure-directing agent in the synthesis of titanoborosilicate precursor.[1]
• As stock solution with NMP (1-methyl-2-pyrrolidinone) to deprotect the Fmoc group in the preparation of N-methylated cyclic peptides.[2]

Features and Benefits

Piperidine is more basic than pyridine and also a good nucleophile.[3]

Analysis Note

Assay (GC, area%): ≥ 99.0 % (a/a)
Density (d 20 °C/ 4 °C): 0.861 - 0.863
Water (K. F.): ≤ 0.50 %
Identity (IR): passes test

Safety Information

• Pictograms: GHS02,GHS05,GHS06
• Signal Word: Danger
• Hazard Statements: H225 - H302 - H311 + H331 - H314
• Precautionary Statements: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 1
• Flash Point(F): 60.8 °F - closed cup
• Flash Point(C): 16 °C - closed cup