5.09612

TAPI-2

InSolution, ≥97%, 10 mM aqueous solution, inhibitor of matrix metalloproteinases and TACE (TNF-α convertase; ADAM17)

• Sinónimos: InSolution TAPI-2
• Fórmula empírica (notación de Hill): C₁₉H₃₇N₅O₅
• Número de CAS: 187034-31-7
• Peso molecular: 415.53
• Número MDL: MFCD00040626
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥97% (HPLC)
• Formulario: liquid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• temp. de almacenamiento: −70°C

Descripción

Descripción general

A hydroxamate-based inhibitor of matrix metalloproteinases and TACE (TNF-α convertase; ADAM17). Inhibits the activation-dependent shedding of L-selectin from neutrophils, eosinophils, and lymphocytes as well as phenylarsine oxide (PAO)-induced shedding in neutrophils. Also blocks the shedding of several cell surface proteins such as pro-TGF-α, IL-6 receptor α-subunit, and β-amyloid precursor protein. Reported to inhibit TNF-α release and impart protection against aspirin-induced gastric mucosal injury. Acts as a weak inhibitor of angiotensin converting enzyme (IC₅₀ = 18 µM).

Envase

Packaged under inert gas

Advertencia

Toxicity: Standard Handling (A)

Forma física

A 10 mM (1 mg/241 µL) sterile-filtered solution of TAPI-2 (Cat. No. 579052) in H₂O.

Reconstitución

Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 3 months at -20°C.

Otras notas

Bennett, T.A., et al. 2000. J. Immunol.164, 4120.
Fiorucci, S., et al. 1998. Aliment. Pharmacol. Ther.12, 1139.
Hooper, N.M., et al. 1997. Biochem. J.321, 265.
Parvathy, S., et al. 1997. Biochem. J.327, 37.
Arribas, J., et al. 1996. J. Biol. Chem.271, 11376.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany