P9767

Sodium palmitate

≥98.5%

• Synonym(s): Hexadecanoic acid sodium salt, Palmitic acid sodium salt
• Linear Formula: CH₃(CH₂)₁₄COONa
• CAS Number: 408-35-5
• Molecular Weight: 278.41
• Beilstein: 3575882
• EC Number: 206-988-1
• MDL number: MFCD00002749
• UNSPSC Code: 12352211
• PubChem Substance ID: 24899061
• NACRES: NA.25

Properties

• biological source: plant (palm)
• Assay: ≥98.5%
• form: powder
• mp: 283-290 °C (lit.)
• functional group: ester
• lipid type: saturated FAs
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: [Na+].CCCCCCCCCCCCCCCC([O-])=O
• InChI: 1S/C16H32O2.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18;/h2-15H2,1H3,(H,17,18);/q;+1/p-1
• InChI key: GGXKEBACDBNFAF-UHFFFAOYSA-M

Description

Application

Sodium palmitate (PA) has been used:

• to induce inflammation and thrombosis pathway in murine macrophage cell line RAW 264.7 cell line by activating reactive oxygen species (ROS) production, Janus-kinase (JNK) signalling and release of histone H3 by western blotting and cell viability by MTT assay
• to induce lipogenesis in AML12 cells and primary hepatocytes to analyse the effect of irisin on PA induced lipogenesis and related signal pathways by western blot analysis and quantitative PCR analysis
• as a component in free fatty acid mixture to induce cellular steatosis in HepG2 cell lines and determination of lipid accumulation by Oil-Red-O staining

Biochem/physiol Actions

Sodium palmitate is the sodium salt of palmitic acid, a component in hard soaps. Palmitic acid is a common saturated fatty acid and produced during fatty acid synthesis. Sodium palmitate enhances lipogenesis, cellular steatosis in various cell lines. Palmitate induces cell death in human epidermal growth factor receptor 2 (HER2)/neu-positive cells and breast cancer cell lines like MCF-7 due to enhanced fatty acid accumulation. Sodium palmitate induces lipoapoptosis in L02 and HepG2 liver cells by inducing glycogen synthase kinase-3β (GSK3β) expression.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves