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342M-1

Sigma-Aldrich

Tryptase (G3) Mouse Monoclonal Antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

100
500

conjugate

unconjugated

antibody form

diluted ascites fluid

antibody product type

primary antibodies

clone

G3, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (342M-14)
vial of 0.5 mL concentrate (342M-15)
bottle of 1.0 mL predilute (342M-17)
vial of 1.0 mL concentrate (342M-16)
bottle of 7.0 mL predilute (342M-18)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:200-1:1000

isotype

IgG1

control

uterus

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic

Gene Information

human ... TPSAB1(7177)

General description

Tryptases constitute a subfamily of trypsin-like proteinases, stored in the mast cell secretory granules and basophils. Upon cellular activation, these enzymes are released into the extracellular environment. Anti-tryptase is a good marker for mast cells, basophils, and their derivatives.

Quality


IVD
IVD
IVD
RUO

Linkage

Tryptase Positive Control Slides, Product No. 342S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Certificates of Analysis (COA)

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L K Gordon et al.
Clinical immunology (Orlando, Fla.), 94(1), 42-50 (1999-12-23)
pANCA is a marker antibody expressed in most patients with ulcerative colitis, and its cognate antigen is potentially an immunologic target in this disease. This study evaluates whether pANCA detects an autoantigen that is expressed in the colonic mucosa. Immunohistochemistry
J H Jordan et al.
Human pathology, 32(5), 545-552 (2001-06-19)
In an attempt to identify novel diagnostic markers for mast cell (MC)-proliferative disorders, serial bone marrow (bm) sections of 22 patients with mastocytosis (systemic indolent mastocytosis, n = 19; mast cell leukemia [MCL], n = 1; isolated bm mastocytosis, n
Andreas Chott et al.
The American journal of surgical pathology, 27(7), 1013-1019 (2003-06-27)
Mast cell sarcoma is an extremely rare and aggressive type of mast cell disease. Only a few cases have been described so far, and little is known about the biology and phenotype of afflicted cells. We describe morphologic and immunophenotypic
L Fiorucci et al.
Cellular and molecular life sciences : CMLS, 61(11), 1278-1295 (2004-06-02)
Tryptases constitute a subfamily of trypsin-like proteinases, stored in the mast cell secretory granules of all mammalian organisms. These enzymes are released along with other mediators into the extracellular medium upon mast cell activation/degranulation. Among the trypsin-like enzymes, tryptases are
I S Roberts et al.
Journal of clinical pathology, 53(11), 858-862 (2000-12-29)
Mast cells, when activated, secrete a large number of fibrogenic factors and have been implicated in the development of fibrotic conditions of the liver, lung, and skin. There is evidence that renal fibrosis is closely linked with a chronic inflammatory
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