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MADKMAG-71K

Millipore

MILLIPLEX® Mouse Adipokine Magnetic Bead Panel - Endocrine Multiplex Assay

The analytes available for this multiplex kit are: IL-6, Insulin, Leptin, MCP-1, PAI-1 (Total), Resistin, TNF-α.

Synonym(s):

luminex mouse adipokine multiplex kit, luminex mouse obesity multiplex kit, millipore mouse metabolic syndrome disease multiplex, mouse metabolism diabetes immunoassay panel

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About This Item

UNSPSC Code:
12161503
eCl@ss:
32161000
NACRES:
NA.84

Quality Level

200

species reactivity

mouse

manufacturer/tradename

Milliplex®

assay range

accuracy: 77-92%
standard curve range: 12.2-50,000 pg/mL

technique(s)

multiplexing: suitable

detection method

fluorometric (Luminex xMAP)

shipped in

wet ice

Related Categories

General description

The discovery of leptin secretion from adipocytes in 1994 led to the recognition that white adipose tissue is involved in a variety of metabolic and physiological processes. Adipocytes secrete several hormones called adipokines with functions that include appetite and energy balance, insulin sensitivity and lipid metabolism.

MILLIPLEX® Mouse Adipokine Panel is a 7-plex kit to be used for the simultaneous quantification of any or all of the following analytes in mouse serum and plasma samples: IL-6, Insulin, Leptin, MCP-1, PAI-1 Total, Resistin and TNFα. This kit uses a 96-well format, contains a lyophilized standard cocktail, two internal assay quality controls and can measure up to 38 samples in duplicate.

The Luminex® xMAP® platform uses a magnetic bead immunoassay format for ideal speed and sensitivity to quantitate multiple analytes simultaneously, dramatically improving productivity while conserving valuable sample volume.

Panel Type: Metabolism

Specificity

Cross Reactivty
Each antibody pair in a panel is highly specific and displays insignificant cross-reactivity to other analytes in the panel.

Application

  • Analytes: IL-6, Insulin, Leptin, MCP-1 (CCL2), PAI-1 (Total), Resistin, TNF-α
  • Recommended Sample Type: Mouse serum and plasma
  • Recommended Sample Dilution: 10 μL per well of undilute d serum or plasma
  • Assay Run Time: Overnight (16-18 hours) at 2-8°C.
  • Research Category: Metabolism
  • Research Subcategory: Endocrine, Obesity, Metabolic Disorders

Features and Benefits

Design your multiplex kit by choosing available analytes within this panel.

Other Notes

Sensitivity: Please see kit protocol for sensitive’s of individual biomarkers.

Legal Information

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Pictograms

Exclamation markEnvironment
GHS07,GHS09

Signal Word

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Skin Sens. 1

Storage Class Code

10 - Combustible liquids

Certificates of Analysis (COA)

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Michaela D Wharfe et al.
American journal of physiology. Endocrinology and metabolism, 311(3), E575-E586 (2016-07-14)
Adaptations in maternal carbohydrate metabolism are particularly important in pregnancy because glucose is the principal energy substrate used by the fetus. As metabolic homeostasis is intricately linked to the circadian system via the rhythmic expression of clock genes, it is
Micah L Battson et al.
American journal of physiology. Endocrinology and metabolism, 314(5), E468-E477 (2018-01-20)
Vascular dysfunction represents a critical preclinical step in the development of cardiovascular disease. We examined the role of the gut microbiota in the development of obesity-related vascular dysfunction. Male C57BL/6J mice were fed either a standard diet (SD) ( n
Dimiter Avtanski et al.
Animal models and experimental medicine, 2(4), 252-258 (2020-01-17)
Animal models of diet-induced obesity (DIO) are commonly used in medical research for mimicking human diseases. There is no universal animal model, and careful evaluation of variety of factors needs to be considered when designing new experiments. Here, we investigated
Sara A DiVall et al.
PloS one, 10(3), e0119995-e0119995 (2015-03-18)
Infertility associated with obesity is characterized by abnormal hormone release from reproductive tissues in the hypothalamus, pituitary, and ovary. These tissues maintain insulin sensitivity upon peripheral insulin resistance. Insulin receptor signaling may play a role in the dysregulation of gonadotropin-releasing
Salman Azhar et al.
Molecular and cellular endocrinology, 480, 1-11 (2018-10-06)
Previously, apoE-derived ABCA1 agonist peptides have been shown to possess anti-atherosclerotic and possibly antidiabetic properties. Here we assessed the in vitro and in vivo actions of a second generation of ABCA1 peptide agonists, CS6253 and T6991-2, on glucose homeostasis. The
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