567703

Spermine NONOate

Complex of nitric oxide (NO) with spermine.

• Synonym(s): Spermine NONOate, N-(2-Aminoethyl)-N-(2-hydroxy-2-nitrosohydrazino)-1,2-ethylenediamine, NOC-22
• Empirical Formula (Hill Notation): C₁₀H₂₆N₆O₂
• CAS Number: 136587-13-8
• Molecular Weight: 262.35
• MDL number: MFCD00210215
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• assay: ≥98% (UV)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic)
• color: white
• solubility: 0.1 M NaOH: soluble; water: soluble
• shipped in: ambient
• storage temp.: −20°C
• InChI: 1S/C10H26N6O2/c11-5-3-8-13-7-1-2-9-15(10-4-6-12)16(18)14-17/h13,18H,1-12H2/p+3
• InChI key: QPIOUFBAROSIAN-UHFFFAOYSA-Q

Description

General description

Complex of nitric oxide (NO) with spermine. Convenient reagent for preparing aqueous solutions of NO. Half-life (t_½) of NO release = 230 min (PBS, pH 7.4, 22°C).

Complex of nitric oxide (NO) with spermine. Convenient reagent for preparing aqueous solutions of NO. Half-life (t_½)in PBS, pH 7.4 is 230 minutes at 22°C. Relatively stable in alkaline solution (≥pH 10.0).

Biochem/physiol Actions

Cell permeable: no

Primary Target
Convenient reagent for preparing aqueous solutions of NO

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Other Notes

Ramamurthi, A. and Lewis, R.S. 1997. Chem. Res. Toxicol. 10, 408.
Hrabie, J.A., et al. 1993. J. Org. Chem.58, 1472.
Maragos, C.M., et al. 1993. Cancer Res. 53, 564.
Wink, D.A., et al. 1993. Proc. Natl. Acad. Sci. USA90, 9813.
Maragos, C.M., et al. 1991. J. Med. Chem. 34, 3242.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable