Dihydroorotate dehydrogenase Inhibitors Target c-Myc and Arrest Melanoma, Myeloma and Lymphoma cells at S-phase.

Dihydroorotate dehydrogenase Inhibitors Target c-Myc and Arrest Melanoma, Myeloma and Lymphoma cells at S-phase.

Journal of Cancer (2017-09-21)

Mathura Subangari Dorasamy, Bhavesh Choudhary, Kavitha Nellore, Hosahalli Subramanya, Pooi-Fong Wong

RESUMEN

Dihydroorotate dehydrogenase (DHODH) is a rate-limiting enzyme in the

MATERIALES

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Sigma-Aldrich

Triton^™ X-100, laboratory grade

Sigma-Aldrich

Phenazine methosulfate

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MISSION^® esiRNA, targeting human DHODH