1670207

Tolcapone

United States Pharmacopeia (USP) Reference Standard

• Sinónimos: 3,4-Dihydroxy-4′-methyl-5-nitrobenzophenone, Ro 40-7592
• Fórmula empírica (notación de Hill): C₁₄H₁₁NO₅
• Número CAS: 134308-13-7
• Peso molecular: 273.24
• NACRES: NA.24
• PubChem Substance ID: 329751344
• UNSPSC Code: 41116107
• MDL number: MFCD00866569

Propiedades

• grade: pharmaceutical primary standard
• agency: USP
• API family: tolcapone
• manufacturer/tradename: USP
• application(s): pharmaceutical; pharmaceutical (small molecule); pharmaceutical
• format: neat
• SMILES string: Cc1ccc(cc1)C(=O)c2cc(O)c(O)c(c2)[N+]([O-])=O
• InChI: 1S/C14H11NO5/c1-8-2-4-9(5-3-8)13(17)10-6-11(15(19)20)14(18)12(16)7-10/h2-7,16,18H,1H3
• InChI key: MIQPIUSUKVNLNT-UHFFFAOYSA-N
• Gene Information: human ... COMT(1312)

Descripción

General description

Find answers to frequently asked questions on USP products in USP FAQs.

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Tolcapone USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Tolcapone Tablets

Biochem/physiol Actions

Orally active catechol-O-methyltransferase (COMT) inhibitor: inhibits both central and peripheral COMT.

Tolcapone is an orally active catechol-O-methyltransferase (COMT) inhibitor. It inhibits both central and peripheral COMT. Tolcapone crosses the blood-brain barrier, and has been used for L-DOPA adjunct therapy in the treatment of Parkinson′s Disease.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Información de seguridad

• Pictogramas: GHS09
• Palabra de advertencia: Warning
• Códigos de peligro: H400
• Indicaciones de precaución: P273 - P391 - P501
• Hazard Classifications: Aquatic Acute 1
• Clase de almacenamiento: 11 - Combustible Solids
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable