1478403

Olopatadine hydrochloride

United States Pharmacopeia (USP) Reference Standard

• Sinónimos: (11Z)-11-[3-(Dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid hydrochloride, AL-4943A, KW-4679, Opatanol, Patanol
• Fórmula empírica (notación de Hill): C₂₁H₂₃NO₃·HCl
• Número CAS: 140462-76-6
• Peso molecular: 373.87
• NACRES: NA.24
• PubChem Substance ID: 329750608
• UNSPSC Code: 41116107
• MDL number: MFCD00875716

Propiedades

• grade: pharmaceutical primary standard
• agency: USP
• API family: olopatadine
• manufacturer/tradename: USP
• application(s): pharmaceutical (small molecule); pharmaceutical
• format: neat
• SMILES string: Cl.CN(C)CC\C=C1\c2ccccc2COc3ccc(CC(O)=O)cc13
• InChI: 1S/C21H23NO3.ClH/c1-22(2)11-5-8-18-17-7-4-3-6-16(17)14-25-20-10-9-15(12-19(18)20)13-21(23)24;/h3-4,6-10,12H,5,11,13-14H2,1-2H3,(H,23,24);1H/b18-8-;
• InChI key: HVRLZEKDTUEKQH-NOILCQHBSA-N
• Gene Information: human ... HRH1(3269)

Descripción

General description

Find answers to frequently asked questions on USP products in USP FAQs.

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Olopatadine hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Olopatadine Hydrochloride Ophthalmic Solution

Biochem/physiol Actions

Olopatadine is a dual acting histamine H1-receptor antagonist and mast cell stabilizer.

Olopatadine is a histamine H1 receptor antagonist and mast cell stabilizer. The low level of occupancy H1 receptors in the brain explains the low sedation effect of olopatidine. It is believed that olopatidine is a substrate for P-glycoprotein, which limits its brain penetration.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Información de seguridad

• Pictogramas: GHS06,GHS09
• Palabra de advertencia: Danger
• Códigos de peligro: H301,H400
• Indicaciones de precaución: P273 - P301 + P310 + P330
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Acute 1
• Clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable