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No; Sigma-Aldrich has no source for pure 2,3,7,8-Tetrachlorodibenzo-p-dioxin. It is only available as Supelco 48599: 2,3,7,8-TCDD, 10 μg/mL in toluene, ampule of 1mL.
48599
2,3,7,8-Tetrachlorodibenzo-p-dioxin solution
analytical standard
Sinónimos:
2,3,7,8-TCDD
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About This Item
Productos recomendados
grado
analytical standard
CofA
current certificate can be downloaded
envase
ampule of 1 mL
temp. de almacenamiento
2-8°C
InChI
1S/C12H4Cl4O2/c13-5-1-9-10(2-6(5)14)18-12-4-8(16)7(15)3-11(12)17-9/h1-4H
Clave InChI
HGUFODBRKLSHSI-UHFFFAOYSA-N
Descripción general
2,3,7,8-Tetrachlorodibenzo-p-dioxin is a highly distributed environmental contaminant[1], released by industrial activities, which can act like as a reproductive toxicant and endocrine disruptor in all vertebrates.[2]
2,3,7,8-Tetrachlorodibenzo-p-dioxin is the most potent congener of dioxins and dioxin-like chemicals, which can exert adverse effects in laboratory animals used in testing.[3]
Aplicación
2,3,7,8-Tetrachlorodibenzo-p-dioxin solution has been used as standard in investigating the effect of 2,3,7,8-Tetrachlorodibenzo-p-dioxin to offsprings of fish, using high performance gas chromatography coupled with high performance mass spectrometry (HPGC-HPMS).[2]
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Palabra de señalización
Danger
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Aquatic Chronic 1 - Asp. Tox. 1 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 2 - STOT SE 3
Órganos de actuación
Central nervous system
Código de clase de almacenamiento
3 - Flammable liquids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
39.2 °F - closed cup
Punto de inflamabilidad (°C)
4 °C - closed cup
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E C Rada et al.
Chemosphere, 110, 53-61 (2014-06-02)
Atmospheric depositions of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and polychlorinated biphenyls (PCBs) were monitored at three sites in the vicinity of a steel making plant, located in an Italian alpine valley. A high variability in the deposition of PCDD/Fs was
Filomena Fiorito et al.
Toxicology, 290(2-3), 258-270 (2011-10-22)
The administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to a variety of cultured cells may alter their ability to proliferate and die. In a previous study we demonstrated that TCDD induced proliferation in Madin-Darby Bovine Kidney (MDBK) cells where no signs of apoptosis
Maria Herlin et al.
Toxicology and applied pharmacology, 273(1), 219-226 (2013-09-17)
Bone is a target for high affinity aryl hydrocarbon receptor (AHR) ligands, such as dioxins. Although bone morphology, mineral density and strength are sensitive endpoints of dioxin toxicity, less is known about effects on bone microarchitecture and material properties. This
K A Solak et al.
Toxicology, 311(3), 124-134 (2013-07-23)
The aryl hydrocarbon receptor (AhR) is involved in a wide variety of biological and toxicological responses, including neuroendocrine signaling. Due to the complexity of neuroendocrine pathways in e.g. the hypothalamus and pituitary, there are limited in vitro models available despite
Tomoki Takeda et al.
Molecular pharmacology, 85(1), 74-82 (2013-10-18)
Our previous studies have shown that treatment of pregnant rats with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; 1 μg/kg) at gestational day (GD) 15 reduces the pituitary synthesis of luteinizing hormone (LH) during the late fetal and early postnatal period, leading to the imprinting
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Can I get pure 2,3,7,8-Tetrachlorodibenzo-p-dioxin from Sigma-Aldrich?
1 answer-
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What is the molecular weight of 2,3,7,8-Tetrachlorodibenzo-p-dioxin, Product 48599?
1 answer-
The molecular weight of 2,3,7,8-TCDD is 321.97 Da.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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Is Product No. 48599, 2,3,7,8-Tetrachlorodibenzo-p-dioxin solution, appropriate for use in tissue culture studies?
1 answer-
The 2,3,7,8-Tetrachlorodibenzo-p-dioxin solution (10 μg/mL in toluene), is sold as 1mL in a flame sealed ampule. It is made to be used as a chemical standard with US EPA drinking and wastewater analytical methods. We have no knowledge of its use in tissue culture.
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