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X4875

Xanthine Oxidase from bovine milk

Grade IV, ammonium sulfate suspension, ≥0.1 units/mg protein

Sinónimos:

XOD, Xanthine:oxygen oxidoreductase

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10 UNITS

$85.00

40 UNITS

$253.00

120 UNITS

$611.00

$85.00

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Número CAS:
9002-17-9
UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
232-657-6
MDL number:
MFCD00082145
Número CE:
1.17.3.2.
Specific activity:
≥0.1 units/mg protein
Biological source:
bovine milk

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biological source

bovine milk

type

Grade IV

form

ammonium sulfate suspension

specific activity

≥0.1 units/mg protein

storage temp.

2-8°C

Quality Level

200

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Este artículo
X4376X4500X1875
Xanthine Oxidase from bovine milk Grade IV, ammonium sulfate suspension, ≥0.1 units/mg protein

Sigma-Aldrich

X4875

Xanthine Oxidase from bovine milk

Xanthine Oxidase from bovine milk lyophilized powder, 0.4-1.0 units/mg protein

Sigma-Aldrich

X4376

Xanthine Oxidase from bovine milk

Xanthine Oxidase from bovine milk Grade III, ammonium sulfate suspension, ≥0.8 units/mg protein

Sigma-Aldrich

X4500

Xanthine Oxidase from bovine milk

Xanthine Oxidase from bovine milk Grade I, ammonium sulfate suspension, ≥0.4 units/mg protein

Sigma-Aldrich

X1875

Xanthine Oxidase from bovine milk

specific activity

≥0.1 units/mg protein

specific activity

0.4-1.0 units/mg protein

specific activity

≥0.8 units/mg protein

specific activity

≥0.4 units/mg protein

biological source

bovine milk

biological source

bovine milk

biological source

bovine milk

biological source

-

form

ammonium sulfate suspension

form

lyophilized powder

form

ammonium sulfate suspension

form

ammonium sulfate suspension

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Quality Level

200

Quality Level

300

Quality Level

200

Quality Level

200

type

Grade IV

type

-

type

Grade III

type

Grade I

General description

Research area: Cell CycleXanthineoxidase (XO) is a homodimer. It is made up of two sub-units each made up of onemolybdenum and two iron-sulphur (2Fe-2S) centers.
Formerly E.C. 1.1.3.22

Application

Xanthine Oxidase from bovine milk has been used in superoxide dismutaseactivity assay.[1]Xanthine oxidase may be suitable for producing amperometric biosensors and designing-flavonoid-type inhibitors against XO for treating inflammatory diseases, gout, and hyperuricemia. It may also be used in the synthesis of superoxide because of aldehyde oxidation.

Biochem/physiol Actions

Xanthine oxidase is a molybdenum-containing enzyme that is found in the cytosol, and may be strongly inhibited by flavonoids. It plays a vital role in the metabolism of some drugs, as well as purines and pyrimidines. It is also known to be a biological source of reactive oxygen species.
Although xanthine oxidase is found widely distributed in multiple tissues, it is highly expressed in endothelial and epithelial cells. Its expression was also increased in infected tissues where it was shown to have an anti-microbial effect due to its ability to generate reactive oxygen species. [2]Xanthineoxidase plays an important role in catalyzing the hydroxylation ofhypoxanthine to Xanthine. Later, xanthine is converted to uric acid isexcreted by the kidneys.

Physical form

Suspension in 2.3 M (NH4)2SO4 containing 1 mM sodium salicylate

Analysis Note

Protein determined by biuret

Other Notes

One unit will convert 1.0 μmole of xanthine to uric acid per min at pH 7.5 at 25 °C. Approx. 50% of the activity is obtained with hypoxanthine as substrate.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H334

Hazard Classifications

Resp. Sens. 1

Clase de almacenamiento

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
0000532494
0000532495
0000532494
0000532495
0000500183

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Visite la Librería de documentos

Evolution of the anticholinesterase, antioxidant, and anti-inflammatory activity of Epilobium angustifolium L. infusion during in vitro digestion
Szwajgier D, et al.
Journal of functional foods, 85, 104645-104645 (2021)
Role of xanthine oxidoreductase as an antimicrobial agent.
Hannah M Martin et al.
Infection and immunity, 72(9), 4933-4939 (2004-08-24)
Szymon Byczkiewicz et al.
Nutrients, 16(11) (2024-06-19)
In the present study, the effect of the addition of quince and collagen type I and III to dessert chocolate on its functional properties was determined. The study evaluated the antioxidant potential of the tested formulations using the FRAP method
M B Betancor et al.
Fish physiology and biochemistry, 41(3), 705-720 (2015-03-10)
In vertebrates, selenium (Se) is an essential micronutrient for vertebrates that is involved in antioxidant protection and thyroid hormone regulation among other roles and functions through its incorporation into proteins, the selenoproteins. Long-chain polyunsaturated fatty acids, such as docosahexaenoic acid
Xanthine oxidase: isolation, assays of activity, and inhibition
Kostic D, et al.
Journal of Chemistry, 2015(1), 294858-294858 (2015)
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Questions

  1. Hello, Is there a way to find out how much 2.3M (NH4)2SO4 was used to suspend 10 Units of Xanthine Oxidase? Specifically, what is the ratio of units Xanthine Oxidase (or mg) to volume needed to create this suspension using lyophilized powder? Thank you!

    1 answer

    1. The volume of a given package size varies from lot to lot. The minimum activity of this product is 0.1 units per milligram of protein. The minimum protein concentration is 5.0 mg/mL. As an example, a lot reporting an activity of 0.3 units per milligram protein at a concentration of 13.8 mg protein per milliliter, will have a volume of 2.3 mL for the 10 Unit package size. This is determined by using the following calculation:
      10U / (0.3U/mg) = 30mg / (13.8mg/ml) = 2.3 ml volume

      The lot-specific volume may be determined by data provided in the Certificate of Analysis. Please see the link below to review a sample or lot-specific Certificate:
      https://www.sigmaaldrich.com/product/sigma/x4875#product-documentation

      Helpful?

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