T9177
Tyrphostin AG 126
≥90%
Sinónimos:
(3-Hydroxy-4-nitrobenzylidene)malononitrile
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About This Item
Fórmula empírica (notación de Hill):
C10H5N3O3
Número de CAS:
Peso molecular:
215.17
Número MDL:
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
Ensayo
≥90%
temp. de almacenamiento
−20°C
cadena SMILES
Oc1cc(ccc1[N+]([O-])=O)\C=C(\C#N)C#N
Información sobre el gen
human ... TNF(7124)
Aplicación
Tyrphostin AG 126 has been used in LOPAC screening assays to identify histone deacetylase (HDAC) inhibitors.
Acciones bioquímicas o fisiológicas
Tyrphostin AG 126 is a tyrosine kinase inhibitor that is known to block the production of tumor necrosis factor-alpha (TNF-alpha) and nitric oxide in macrophages. Furthermore, studies have reported that AG 126 can reduce zymosan-induced multiple organ failure in rats, block the postoperative ileus development in mice, and also decrease colitis development in rats.
Código de clase de almacenamiento
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
Clase de riesgo para el agua (WGK)
WGK 3
Equipo de protección personal
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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Hua Yuan et al.
American journal of physiology. Heart and circulatory physiology, 296(2), H470-H479 (2008-12-23)
Bacterial endotoxin lipopolysaccharide (LPS) is responsible for the multiorgan dysfunction that characterizes septic shock and is causal in the myocardial depression that is a common feature of endotoxemia in patients. In this setting the myocardial dysfunction appears to be due
Klemens Angstwurm et al.
Infection and immunity, 72(6), 3294-3298 (2004-05-25)
Bacterial meningitis is an acute inflammatory disease of the central nervous system with a mortality rate of up to 30%. Excessive stimulation of the host immune system by bacterial surface components contributes to this devastating outcome. In vitro studies have
Beverley A Moore et al.
American journal of physiology. Gastrointestinal and liver physiology, 286(2), G214-G224 (2003-09-27)
Manipulation of the bowel during abdominal surgery leads to a period of ileus, which is most severely manifested after procedures that directly involve the colon. Ileus is associated with the increased expression of proinflammatory cytokines and chemokines, a leukocytic infiltration
Srinivasan Balachandra et al.
Surgery, 138(5), 913-923 (2005-11-18)
The effects of the tyrosine kinase inhibitors, tyrphostin AG126 and AG556 in a murine model of acute pancreatitis are investigated. Intraperitoneal injection of cerulein in mice resulted in a severe, acute pancreatitis, which was characterized by edema, neutrophil infiltration, tissue
M G Rittig et al.
Cellular microbiology, 5(12), 887-899 (2003-12-04)
Following reports that a VacA+cag+ toxigenic but not a VacA-cag- non-toxigenic Helicobacter pylori strain induced homotypic phagosome fusion in murine macrophages, we addressed that phenomenon in human cells. Mononuclear phagocytes and epitheloid cells were challenged with H. pylori strains of
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