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MilliporeSigma

T4930

Sigma-Aldrich

Anti-Thrombopoietin antibody produced in goat

affinity isolated antibody, lyophilized powder

Sinónimos:

Anti-TPO

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About This Item

MDL number:
UNSPSC Code:
51111800
NACRES:
NA.41

biological source

goat

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

mouse

technique(s)

indirect ELISA: suitable
neutralization: suitable
western blot: suitable

UniProt accession no.

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

mouse ... Thpo(21832)

Categorías relacionadas

General description

This antibody will neutralize the biological activity of recombinant mouse TPO. By ELISA, the antibody shows <15% cross-reactivity with recombinant human TPO.

Immunogen

recombinant mouse TPO.

Biochem/physiol Actions

Thrombopoietin is a humoral growth factor that is synthesized in the liver and regulates the proliferation and maturation of megakaryocytes, and production of platelets. It modulates the response of platelets to various stimuli by regulating the homeostatic potential.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 5% trehalose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Bernhard Wörmann
Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie, 40(5), 319-325 (2013-11-26)
Thrombocytopenia is a common hematologic disorder. Stimulation of thrombopoiesis may reduce the risk for thrombocytopenia-induced bleeding, prevent severe thrombocytopenia, and reduce the need for platelet transfusion. The key cytokine is thrombopoietin (TPO). It regulates proliferation and maturation of megakaryocytes as
Enrico Lupia et al.
Mediators of inflammation, 2012, 390892-390892 (2012-05-12)
Thrombopoietin (TPO) is a humoral growth factor originally identified for its ability to stimulate the proliferation and differentiation of megakaryocytes. In addition to its actions on thrombopoiesis, TPO directly modulates the homeostatic potential of mature platelets by influencing their response

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