SRP5114
P73b, GST tagged human
recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Sinónimos:
TAp73β, TP73
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50 μG
$270.00
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50 μG
$270.00
About This Item
origen biológico
human
recombinante
expressed in baculovirus infected Sf9 cells
Ensayo
≥70% (SDS-PAGE)
Formulario
buffered aqueous glycerol solution
mol peso
~88 kDa
Nº de acceso NCBI
aplicaciones
cell analysis
Condiciones de envío
dry ice
temp. de almacenamiento
−70°C
Información sobre el gen
human ... TP73(7161)
Descripción general
p73β is a member of the p53 family of transcription factors involved in cellular responses to stress and development. The p73 protein is expressed at very low levels in normal tissues and is differentially expressed in a number of tumors. P73β is strongly involved in malignancy acquisition and maintenance. p73 is a stress-response gene that activates transcription of p53-responsive genes and inhibits cell growth in a p53-like manner by inducing apoptosis. p73 is a component of a mismatch repair-dependent apoptosis pathway, which contributes to cisplatin-induced cytotoxicity. The regulation of p73 by c-Abl in response to DNA damage was also demonstrated by a failure of ionizing radiation-induced apoptosis after disruption of c-Abl-p73 interaction.
Forma física
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Nota de preparación
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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C A Jost et al.
Nature, 389(6647), 191-194 (1997-09-20)
The protein p53 is the most frequently mutated tumour suppressor to be identified so far in human cancers. The ability of p53 to inhibit cell growth is due, at least in part, to its ability to bind to specific DNA
J G Gong et al.
Nature, 399(6738), 806-809 (1999-07-03)
Cancer chemotherapeutic agents such as cisplatin exert their cytotoxic effect by inducing DNA damage and activating programmed cell death (apoptosis). The tumour-suppressor protein p53 is an important activator of apoptosis. Although p53-deficient cancer cells are less responsive to chemotherapy, their
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