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SRP5008

Sigma-Aldrich

CDK1/CyclinA1, active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sinónimos:

CCNA1, CDC2

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About This Item

Código UNSPSC:
12352200
NACRES:
NA.32

recombinante

expressed in baculovirus infected Sf9 cells

Línea del producto

PRECISIO® Kinase

Ensayo

≥70% (SDS-PAGE)

Formulario

buffered aqueous glycerol solution

actividad específica

32-48 nmol/min·mg

mol peso

~58 kDa (CDK1)
 ~81 kDa (CyclinA1)

Nº de acceso NCBI

BC036346
NM_001786

Condiciones de envío

dry ice

temp. de almacenamiento

−70°C

Información sobre el gen

human ... CCNA1(8900) , CDK1(983)

Descripción general

CDK1 or Cell Division Control protein 1 is essential for the completion of START, the controlling event in the cell cycle that is required to initiate mitosis. CDK1 is a catalytic subunit of a protein kinase complex, called the M-Phase Promoting Factor that induces entry into mitosis and is universal among eukaryotes. Phosphorylation of Bcl-2 in G2/M phase-arrested cells following photodynamic therapy with hypericin involves a CDK1-mediated signal and delays the onset of apoptosis. Therapeutic potential of CDK inhibitor NU2058 in androgen-independent prostate cancer has also been demonstrated.

Forma física

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Nota de preparación

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

Información legal

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
I208-1

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James N Brandt et al.
The Journal of cell biology, 219(11) (2020-10-01)
Polo-like kinases (PLKs) play widely conserved roles in orchestrating meiotic chromosome dynamics. However, how PLKs are targeted to distinct subcellular localizations during meiotic progression remains poorly understood. Here, we demonstrate that the cyclin-dependent kinase CDK-1 primes the recruitment of PLK-2
A C Rigas et al.
Oncogene, 26(55), 7611-7619 (2007-06-30)
Antiandrogens are initially effective in controlling prostate cancer (CaP), the second most common cancer in men, but resistance, associated with the loss of androgen-regulated cell cycle control, is a major problem. At present there is no effective treatment for androgen-independent
Annelies Vantieghem et al.
The Journal of biological chemistry, 277(40), 37718-37731 (2002-07-09)
The role of Bcl-2 in photodynamic therapy (PDT) is controversial, and some photosensitizers have been shown to induce Bcl-2 degradation with loss of its protective function. Hypericin is a naturally occurring photosensitizer with promising properties for the PDT of cancer.

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