SRP4066

FGF-21 human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

• Sinónimos: FGF21, FGFL, Fibroblast growth factor 21
• UNSPSC Code: 12352202
• NACRES: NA.32

Propiedades

• biological source: human
• recombinant: expressed in E. coli
• assay: ≥95% (SDS-PAGE)
• form: lyophilized
• mol wt: ~19.5 kDa
• packaging: pkg of 10 μg
• storage condition: avoid repeated freeze/thaw cycles
• impurities: endotoxin, tested
• NCBI accession no.: AB021975
• UniProt accession no.: Q9NSA1
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... FGF21(26291)

Descripción

General description

FGF21 (fibroblast growth factor) belongs to FGF superfamily. It is generated by the liver. The gene is mapped to human chromosome 19q13.33.
Recombinant Human FGF-21 produced in Escherichia coli is a single, non-glycosylated polypeptide chain containing 182 amino acids and having a molecular mass of 19.5kDa.

Biochem/physiol Actions

FGF21 (fibroblast growth factor) is a hormonal factor which controls glucose homeostasis and energy metabolism. It exhibits anti-diabetic properties by controlling glucose uptake in peripheral tissues. It also possesses autocrine effects in white adipose tissue. FGF21 is present in milk and is needed for intestinal function in the neonate. It is also involved in bone loss. FGF21 exhibits hepatoprotective properties.

Physical form

Lyopohilized from 10 mM Tris, pH 7.5 plus 100 mM NaCl.

Reconstitution

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Reconstitute the lyophilized product with sterile water at a concentration of 0.1 mg/mL, which can be further diluted into other aqueous solutions.

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable