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SRP3149

Sigma-Aldrich

sCD14 human

recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE), ≥95% (HPLC), suitable for cell culture

Sinónimos:

soluble CD14

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32

biological source

human

recombinant

expressed in HEK 293 cells

assay

≥95% (HPLC)
≥95% (SDS-PAGE)

form

lyophilized

mol wt

41.6 kDa

packaging

pkg of 50 μg

technique(s)

cell culture | mammalian: suitable

impurities

<0.1 EU/μg endotoxin, tested

color

white

UniProt accession no.

P08571

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... CD14(929)

Sequence

TTPEPCELDD EDFRCVCNFS EPQPDWSEAF QCVSAVEVEI HAGGLNLEPF LKRVDADADP RQYADTVKAL RVRRLTVGAA QVPAQLLVGA LRVLAYSRLK ELTLEDLKIT GTMPPLPLEA TGLALSSLRL RNVSWATGRS WLAELQQWLK PGLKVLSIAQ AHSPAFSCEQ VRAFPALTSL DLSDNPGLGE RGLMAALCPH KFPAIQNLAL RNTGMETPTG VCAALAAAGV QPHSLDLSHN SLRATVNPSA PRCMWSSALN SLNLSFAGLE QVPKGLPAKL RVLDLSCNRL NRAPQPDELP EVDNLTLDGN PFLVPGTALP HEGSMNSGVV P

Physical form

Lyophilized from 10 mM Sodium Phosphate, pH 7.5.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Proteolysis of monocyte CD14 by human leukocyte elastase inhibits lipopolysaccharide-mediated cell activation.
Le-Barillec K
The Journal of Clinical Investigation, 103(7), 1039-1046 (1999)
Time to abandon dogma: CD14 is expressed by non-myeloid lineage cells.
Jersmann HP
Immunology and Cell Biology, 83(5), 462-467 (2005)
Richard L Kitchens et al.
Journal of endotoxin research, 11(4), 225-229 (2005-09-24)
LPS binding protein (LBP) and CD14 play key roles in promoting innate immunity to Gram-negative bacteria by transferring LPS to the signaling receptor complex, MD-2/Toll-like receptor 4 (TLR4). LBP and soluble CD14 (sCD14) can also inhibit responses to LPS by
Binding of CD14 to Mycoplasma genitalium-derived lipid-associated membrane proteins upregulates TNF-a.
He J
Inflammation, 37(2), 322-330 (2014)
CD14 protein acts as an adaptor molecule for the immune recognition of Salmonella curli fibers.
Rapsinski GJ
The Journal of Biological Chemistry, 288(20), 14178-14188 (2013)
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