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SRP0429

PDE4A10 active human

Name: PDE4A10 active human
Brand: SIGMA

recombinant, expressed in baculovirus infected Sf9 cells, ≥75% (SDS-PAGE)

Sinónimos:

DPDE2, PDE46, phosphodiesterase 4A, cAMP-specific

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About This Item

UNSPSC Code:

12352200

NACRES:

NA.32

biological source

human

recombinant

expressed in baculovirus infected Sf9 cells

assay

≥75% (SDS-PAGE)

form

aqueous solution

specific activity

≥75% (compared to standard)

mol wt

117 kDa

packaging

pkg of 10 μg

NCBI accession no.

NM_001111309

UniProt accession no.

P27815

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... PDE4A(5141)

General description

Human PDE4A10, also known as PDE4A protein isoform 6, transcript variant 3 (GenBank Accession No. NM_001111309) amino acids 2-825 (end) with N-terminal GST-tag, MW= 117 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

Application

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Unit Definition

One unit is defined as the amount of enzyme that will convert 1 pmole of 3?, 5?-cAMP to 5?-AMP per min at 37°C.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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The novel long PDE4A10 cyclic AMP phosphodiesterase shows a pattern of expression within brain that is distinct from the long PDE4A5 and short PDE4A1 isoforms.

I McPhee et al.

Cellular signalling, 13(12), 911-918 (2001-12-01)

In situ hybridisation methods were used to map the distribution of the novel long PDE4A10 isoform in the brain. PDE4A10 distribution was compared to that of the long PDE4A5 isoform and the short PDE4A1 isoform using probes specific for unique

In cardiac myocytes, cAMP elevation triggers the down-regulation of transcripts and promoter activity for cyclic AMP phosphodiesterase-4A10 (PDE4A10).

Angela McCahill et al.

Cellular signalling, 20(11), 2071-2083 (2008-08-30)

Transcripts for the PDE4A10 cyclic AMP phosphodiesterase isoform are present in a wide variety of rat tissues including the heart. Sequence comparisons between the putative human and mouse promoters revealed a number of conserved regions including both an Sp1 and

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