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SRP0328

PADI-3 human

Name: PADI-3 human
Brand: SIGMA

recombinant, expressed in baculovirus infected Sf9 cells, ≥60% (SDS-PAGE)

Sinónimos:

Peptidyl arginine deiminase, type III

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About This Item

UNSPSC Code:

12352200

NACRES:

NA.32

biological source

human

recombinant

expressed in baculovirus infected Sf9 cells

assay

≥60% (SDS-PAGE)

form

aqueous solution

mol wt

75 kDa

packaging

pkg of 10 μg

storage condition

avoid repeated freeze/thaw cycles

concentration

0.25 mg/mL

NCBI accession no.

NM_016233

UniProt accession no.

Q9ULW8

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... PADI3(51702)

General description

Human PADI-3, also known as Peptidyl arginine deiminase, type III, (GenBank Accession No. NM_016233), amino acids 1-664 (end) with C-terminal FLAG-tag, MW= 75 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

application

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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NF-Y and Sp1/Sp3 are involved in the transcriptional regulation of the peptidylarginine deiminase type III gene (PADI3) in human keratinocytes.

Sijun Dong et al.

The Biochemical journal, 397(3), 449-459 (2006-05-05)

Human peptidylarginine deiminase type III gene (PADI3) encodes a crucial post-translational modification enzyme that converts protein-bound arginine residues into citrulline residues. Its expression is restricted to a few cell types, including keratinocytes in the granular layer of the epidermis and

Human peptidylarginine deiminase type III: molecular cloning and nucleotide sequence of the cDNA, properties of the recombinant enzyme, and immunohistochemical localization in human skin.

T Kanno et al.

The Journal of investigative dermatology, 115(5), 813-823 (2000-11-09)

Peptidylarginine deiminase catalyzes the post-translational modification of proteins through the conversion of arginine to citrulline in the presence of calcium ions. In rodents, peptidylarginine deiminase has been classified into four isoforms, types I, II, III, and IV, which are distinct

Peptidylarginine deiminase isoforms 1-3 are expressed in the epidermis and involved in the deimination of K1 and filaggrin.

Rachida Nachat et al.

The Journal of investigative dermatology, 124(2), 384-393 (2005-01-29)

Post-translational conversion of arginine to citrulline residues is catalyzed by peptidylarginine deiminases (PAD). Although the existence of five isoforms of PAD has been reported in rodents and humans, their tissue distribution, substrate specificity, and physiological function have yet to be

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