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Key Documents

SML4072

Tetrahydroberberine

new

≥98% (HPLC)

Sinónimos:

(±)-Canadine, (±)-Tetrahydroberberine, 5,8,13,13a-tetrahydro-9,10-dimethoxy-6H-benzo[g]-1,3-benzodioxolo[5,6-alpha]quinolizine, Canadine

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About This Item

Fórmula empírica (notación de Hill):
C20H21NO4
Número de CAS:
522-97-4
Peso molecular:
339.39
UNSPSC Code:
12352200

biological source

(Corydalis yanhusuo)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (Warmed)

storage temp.

-10 to -25°C

Biochem/physiol Actions

Dopamine receptor antagonist; nicotinic acetylcholine receptor (α4β2, α4β4, α7, α1β, 1γδ) modulator; induces clearance of low-density lipoprotein in mice.

Tetrahydroberberine (Canadine), an isoquinoline alkaloid isolated from corydalis tuber, is a potent dopamine D2 receptor antagonist (pKi = 6.08) and nicotinic acetylcholine receptor (α4β2, α4β4, α7, α1β, 1γδ) modulator. Tetrahydroberberine alleviates high-fat diet-induced hyperlipidemia and induces clearance of low-density lipoprotein and intermediate-density lipoprotein in mice.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Tae Ho Lee et al.
The Journal of pharmacology and experimental therapeutics, 338(3), 917-924 (2011-06-11)
Because delayed gastric emptying and impaired gastric accommodation are regarded as pathophysiological mechanisms underlying functional dyspepsia (FD), prokinetics and fundic relaxants have been suggested as a new treatment for FD. We isolated tetrahydroberberine (THB), an isoquinoline alkaloid (5,8,13,13a-tetrahydro-9,10-dimethoxy-6H-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine) from Corydalis
Guilan Wei et al.
European journal of pharmacology, 968, 176433-176433 (2024-02-19)
The promotion of excess low-density lipoprotein (LDL) clearance stands as an effective clinical approach for treating hyperlipidemia. Tetrahydroberberine, a metabolite of berberine, exhibits superior bioavailability compared to berberine and demonstrates a pronounced hypolipidemic effect. Despite these characteristics, the impact of
Erika Plazas et al.
Pharmacological research, 177, 106126-106126 (2022-02-14)
Complex diseases such as neurodegenerative disorders and cancer constitute a growing public health problem due to the rising incidence and lack in effective therapies. Since pharmacotherapy based on a single target has been insufficient for drug development in complex diseases

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