Orally available, highly potent analog of coenzyme Q10 that modulates the activity of oxidoreductases and improves cell redox status
Vatiquinone (EPI-743), a metabolite of a-tocotrienol, is an orally available and highly potent analog of coenzyme Q10 that modulates the activity of oxidoreductases including AD(P)H:quinone oxidoreductase 1, resulting in increased cellular GSH concentration and improvement in redox status. Vatiquinone is an agent designated to treat mitochondrial diseases.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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We report that α-tocotrienol quinone (ATQ3) is a metabolite of α-tocotrienol, and that ATQ3 is a potent cellular protectant against oxidative stress and aging. ATQ3 is orally bioavailable, crosses the blood-brain barrier, and has demonstrated clinical response in inherited mitochondrial
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