SML3516

EN106

≥98% (HPLC)

• Sinónimos: 2-Chloro-N-(2-cyanoethyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)acetamide
• Fórmula empírica (notación de Hill): C₁₃H₁₃ClN₂O₃
• Número CAS: 757192-67-9
• Peso molecular: 280.71
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD06340076
• Assay: ≥98% (HPLC)
• Form: powder

Propiedades

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=C(CCl)N(C1=CC2=C(OCCO2)C=C1)CCC#N
• InChI key: GLDJSVHDOXCYPT-UHFFFAOYSA-N

Descripción

Biochem/physiol Actions

Cell-permeable covalent recruiter of CUL2 E3 ligase FEM1B that binds to C186 of FEM1B

EN106 is a cell-permeable covalent recruiter of CUL2 E3 ligase FEM1B that binds to C186 of FEM1B. EN106 disrupts FEM1B interactions with the FNIP1 degron and inhibits CUL2FEM1B-dependent ubiquitylation without detectable off-target effects. A modified EN106 bifunctional analog (PROTAC) recruits FEM1B and induces targeted BRD4 and BCR-ABL/c-ABL degradation.

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable