The identity of this product is determined by NMR and Mass Spec. The material has not been tested by IR. A sample Certificate of Analysis can be supplied by our Technical Service team who can assist you further. We kindly ask you to navigate to the link https://www.sigmaaldrich.com/techservice, and click on "Product Documentation" under the Products Section with all the required information so that a member of our team can reach out to you to assist further. Thank you.
SML3388
Vortioxetine hydrobromide
≥98% (HPLC), 5-HT-1D/3A/7 antagonist, powder
Sinónimos:
1-[2-(2,4-Dimethylphenylsulfanyl)phenyl]piperazine hydrobromide, Lu AA21004 HBr, Lu AA21004 hydrobromide, Vortioxetine HBr
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Fórmula empírica (notación de Hill):
C18H22N2S·HBr
Número CAS:
Peso molecular:
379.36
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
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Servicio técnico
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Permítanos ayudarleNombre del producto
Vortioxetine hydrobromide, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
S(c2c(cccc2)N3CC[N+H2]CC3)c1c(cc(cc1)C)C.[Br-]
InChI
1S/C18H22N2S.BrH/c1-14-7-8-17(15(2)13-14)21-18-6-4-3-5-16(18)20-11-9-19-10-12-20;/h3-8,13,19H,9-12H2,1-2H3;1H
InChI key
VNGRUFUIHGGOOM-UHFFFAOYSA-N
Biochem/physiol Actions
Orally active, multimodal serotonergic compound with in vivo psychotropic efficacy by targeting 5-HT-1A/1B/1D/3A/7 and SERT.
Vortioxetine (Lu AA21004) is an orally active, multimodal serotonergic compound with high affinity toward human 5-HT1A (Ki = 15 nM), 5-HT1B (Ki = 33 nM), 5-HT1D (Ki = 54 nM), 5-HT3A (Ki = 3.7 nM), 5-HT7 (Ki = 19 nM), noradrenergic β1 (Ki = 46 nM) receptors, and serotonin (5-HT) transporter (SERT Ki = 1.6 nM). Vortioxetine exhibits in vivo psychotropic efficacy by exerting antagonist activity against 5-HT-1D/3A/7, agonist activity on 5-HT1A, partial agonist activity on 5-HT1B, as well as potent SERT inhibitory activity.
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| description ≥98% (HPLC) | description United States Pharmacopeia (USP) Reference Standard | description Pharmaceutical Analytical Impurity (PAI) | description United States Pharmacopeia (USP) Reference Standard |
| assay ≥98% (HPLC) | assay - | assay - | assay - |
| form powder | form crystalline powder | form - | form powder |
| Quality Level 100 | Quality Level - | Quality Level - | Quality Level - |
| storage temp. 2-8°C | storage temp. - | storage temp. - | storage temp. 2-30°C |
| storage condition desiccated | storage condition - | storage condition - | storage condition - |
| solubility DMSO: 2 mg/mL, clear | solubility - | solubility - | solubility - |
Palabra de advertencia
Warning
Códigos de peligro
Indicaciones de precaución
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2 - STOT RE 2
Órganos diana
Kidney
Clase de almacenamiento
11 - Combustible Solids
¿Qué está pasando?
WGK 3
Punto de inflamación (°F)
Not applicable
Punto de inflamación (°C)
Not applicable
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Dear Sir/Madam, we would like to ask if your Vortioxetine standard is tested by IR, can we get example of CoA? best regards, Tomasz
1 answer-
Helpful?
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