SML3337

CBR-470-1, racemic

≥98% (HPLC)

• Sinónimos: (± )-3-((4-chlorophenyl)sulfonyl)-4-(isobutylamino)tetrahydrothiophene 1,1-dioxide, 3-Thiophenamine, 4-[(4-chlorophenyl)sulfonyl]tetrahydro-N-(2-methylpropyl)-, 1,1-dioxide, (3R,4S)-rel- (ACI)
• Fórmula empírica (notación de Hill): C₁₄H₂₀ClNO₄S₂
• Número CAS: 2416095-06-0
• Peso molecular: 365.90
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD31735115
• Assay: ≥98% (HPLC)
• Form: powder

Propiedades

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2%, clear
• storage temp.: 2-8°C

Descripción

Biochem/physiol Actions

CBR-470-1 is an Inhibitor of the glycolytic enzyme PGK1 that induces Nrf2 activity. PGK1 inhibition results in acculumation of methylglyoxalyl (MGO), a toxic, reactive metabolite removed by other enzymes. The accumulated MGO then irreversibly reacts with Keap1 forming inactive Keap1 dimers, resulting in accumulation of Nrf2.

Inhibitor of the glycolytic enzyme PGK1 inducing Nrf2 activity

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable