SML2671

Cevipabulin fumarate

≥98% (HPLC)

• Sinónimos: 5-Chloro-6-[2,6-difluoro-4-[3-(methylamino)propoxy]phenyl]-N-((1S)-2,2,2-trifluoro-1-methylethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine fumarate, 5-Chloro-6-[2,6-difluoro-4-[3-(methylamino)propoxy]phenyl]-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine, TTI-237 fumarate
• Fórmula empírica (notación de Hill): C₁₈H₁₈ClF₅N₆O · C₄H₄O₄
• Número de CAS: 849550-67-0
• Peso molecular: 580.89
• Número MDL: MFCD31813783
• Código UNSPSC: 41116004
• NACRES: NA.77

Propiedades

• Ensayo: ≥98% (HPLC)
• Formulario: powder
• condiciones de almacenamiento: desiccated
• color: white to beige
• solubilidad: DMSO: 2 mg/mL, clear; H₂O: 5 mg/mL
• temp. de almacenamiento: −20°C
• cadena SMILES: FC1=CC(OCCCNC)=CC(F)=C1C2=C(N[C@@H](C)C(F)(F)F)N3C(N=C2Cl)=NC=N3.O=C(/C=C/C(O)=O)O
• InChI: 1S/C18H18ClF5N6O.C4H4O4/c1-9(18(22,23)24)28-16-14(15(19)29-17-26-8-27-30(16)17)13-11(20)6-10(7-12(13)21)31-5-3-4-25-2;5-3(6)1-2-4(7)8/h6-9,25,28H,3-5H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t9-;/m0./s1
• Clave InChI: TUXZQBYIZLWUKK-AFIAKLHKSA-N

Descripción

Acciones bioquímicas o fisiológicas

Cevipabulin (TTI-237) is a potent microtubule-stabilizing agent that binds to tubulin vinblastine binding site, a typical site of binding for microtubule-destabilizing agents. It is likely that cevipabulin, similarly to other triazolopyrimidines, promotes longitudinal tubulin contacts in microtubules, which promotes stabilization of micro-tubule. Cevipabulin exhibits potent cytotoxic activity in cancer cell lines including cell line expressing a high level of P-glycoprotein. It is active in vivo in several mouse xenograft models of human cancer.

potent microtubule-stabilizing agent that binds to tubulin vinblastine binding site

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable