SML2396

α-DHED

≥98% (HPLC)

• Sinónimos: 10ß,17a-Dihydroxyestra-1,4-dien-3-one, alpha-DHED
• Fórmula empírica (notación de Hill): C₁₈H₂₄O₃
• Número de CAS: 2362514-18-7
• Peso molecular: 288.38
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Ensayo: ≥98% (HPLC)
• Formulario: powder
• color: white to beige
• solubilidad: DMSO: 2 mg/mL, clear
• temp. de almacenamiento: 2-8°C
• cadena SMILES: O[C@@]12C(CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@H]4O)=CC(C=C1)=O
• Clave InChI: UIKDFTLKOKNUJP-ZCVDQKGDSA-N

Descripción

Acciones bioquímicas o fisiológicas

α-DHED is a bioprecursor prodrug of 17α-estradiol ((Alfatradiol)) that results in 17α-estradiol being produced selectively in the brain with little production in the periphery. α-DHED has no estrogenic activity itself with little affinity for either ERα and ERβ estrogen receptors. 17α-estradiol (αE2) has been proposed to have potential roles in various neurodegenerative disorders including neuroprotection of the brain and the prevention/treatment of Alzheimer′s disease, but peripheral side-effects on estrogen-sensitive organs have been problematic. α-DHED, a prodrug without estrogenic activity, could help alleviate those concerns.

Bioprecursor prodrug of 17α-estradiol that results in 17α-estradiol being produced selectively in the brain

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable