The density is not reported for this compound. The molecular weight is 260.33. The solubility is tested at 2mg/mL in DMSO, however other sources suggest that it is soluble in DMSO up to 10mg/mL. This rate has not been validated.
SML2200
Octyl-(R)-2HG
≥98% (HPLC), film, α-KG-dependent dioxygenases prolyl hydroxylases inhibitor
Sinónimos:
(2R)-2-Hydroxyglutarate octyl ester, (2R)-Octyl-α-hydroxyglutarate, 1-Octyl-D-2-hydroxyglutarate, 1-octyl ester, 2R-Hydroxy-pentanedioic acid, Octyl-2HG, Octyl-D-2HG, R-2HG octyl ester
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| Talla/SKU | Disponibilidad | Precio |
|---|---|---|
5 mg | Disponible para enviar HOYdesdeMILWAUKEE | $152.00 |
25 mg | Disponible para enviar HOYdesdeMILWAUKEE | $613.00 |
Acerca de este artículo
Fórmula empírica (notación de Hill):
C13H24O5
Número CAS:
Peso molecular:
260.33
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
film
Storage condition:
desiccated
Servicio técnico
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Permítanos ayudarleNombre del producto
Octyl-(R)-2HG, ≥98% (HPLC)
assay
≥98% (HPLC)
form
film
storage condition
desiccated
color
colorless
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
SMILES string
O[C@H](CCC(=O)O)C(=O)OCCCCCCCC
InChI key
UJZOKTKSGUOCCM-LLVKDONJSA-N
Application
Octyl-(R)-2 hydroxyglutarate (HG) has been used as a membrane permeamble oncometabolite in gliblostoma cells to test its effects on NANOG transcription factor expression. It has also been used as a competitive inhibitor of the enzyme α-ketoglutarate (α-KG)-dependent deoxygenase.
Biochem/physiol Actions
Membrane-permeant precursor form of the oncometabolite D-2-hydroxyglutarate that inhibits α-ketoglutarate/α-KG-dependent dioxygenases.
Octyl-(R)-2HG (Octyl-D-2HG) is a membrane-permeant precursor form of the oncometabolite D-2-hydroxyglutarate (D-2HG) produced by tumor cells due to mutations in the NADP+-dependent isocitrate dehydrogenase genes IDH1 and IDH2. D-2HG inhibits multiple α-ketoglutarate/α-KG-dependent dioxygenases by competing against α-KG binding. Cellular D-2HG delivery by Octyl-(R)-2HG treatment (1-50 mM) is shown to suppress demethylase activity (~148% H3K9me2 and ~310% H3K79me2 upregulation; 50 mM in U-87MG) as well as increase HIF-1α and decrease endostatin levels as a result of inhibiting α-KG-dependent dioxygenases prolyl hydroxylases (PHDs) and collagen prolyl-4-hydroxylase (C-P4H), respectively.
Preparation Note
The density is not reported for this compound. The molecular weight is 260.33. The solubility is tested at 2mg/mL in DMSO, however other sources suggest that it is soluble in DMSO up to 10mg/mL.
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Este artículo | |||
|---|---|---|---|
| description ≥98% (HPLC) | description ≥95% (HPLC) | description non-ionic | description - |
| assay ≥98% (HPLC) | assay ≥95% (HPLC) | assay 99% (GC) | assay - |
| form film | form oil | form - | form - |
| storage temp. −20°C | storage temp. −20°C | storage temp. - | storage temp. 2-8°C |
| storage condition desiccated | storage condition desiccated, under inert gas | storage condition - | storage condition - |
| solubility DMSO: 2 mg/mL, clear | solubility - | solubility - | solubility - |
| color colorless | color colorless to yellow | color - | color - |
Clase de almacenamiento
11 - Combustible Solids
¿Qué está pasando?
WGK 3
Punto de inflamación (°F)
Not applicable
Punto de inflamación (°C)
Not applicable
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What is the density of this product? I can´t find it and I want to have a 100mM stock.
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