SML2143

Ailanthone

≥98% (HPLC), androgen receptor inhibitor, powder

• Sinónimos: Δ13-Dehydrochaparrinone, (1β,11β,12α)-11,20-Epoxy-1,11,12-trihydroxypicrasa-3,13(21)-diene-2,16-dione, 13,21-Didehydrochaparrinone
• Fórmula empírica (notación de Hill): C₂₀H₂₄O₇
• Número CAS: 981-15-7
• Peso molecular: 376.40
• NACRES: NA.77
• UNSPSC Code: 12352200
• EC Number: 683-145-8
• Assay: ≥98% (HPLC)
• Form: powder

Propiedades

• Nombre del producto: Ailanthone, ≥98% (HPLC)
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: −20°C
• SMILES string: O[C@@H]1C([C@]([C@@]2([C@]3([H])[C@@]1(O)OC2)[C@@](O4)([H])C[C@@]([C@]3(C)[C@@H]5O)([H])C(C)=CC5=O)([H])CC4=O)=C
• InChI: 1S/C20H24O7/c1-8-4-12(21)16(24)18(3)10(8)5-13-19-7-26-20(25,17(18)19)15(23)9(2)11(19)6-14(22)27-13/h4,10-11,13,15-17,23-25H,2,5-7H2,1,3H3/t10-,11-,13+,15+,16+,17+,18+,19+,20-/m0/s1
• InChI key: WBBVXGHSWZIJST-RLQYZCPESA-N

Descripción

Biochem/physiol Actions

Ailanthone, natural compound isolated from Ailanthus altissima (Simaroubaceae), is a potent inhibitor of androgen receptor (AR) that blocks activities of full-length AR and AR splice variants. It overcomes MDV3100 (Enzalutamide)-resistance in castration-resistant prostate cancer cell lines. Ailanthone disrupts the interaction between AR and the chaperones HSP90, HSP70, and HSP40, which leads to AR ubiquitination and degradation.

potent inhibitor of androgen receptor (AR) that blocks activities of full-length AR and AR splice variants.

Información de seguridad

• Pictogramas: GHS06
• Palabra de advertencia: Danger
• Códigos de peligro: H300
• Indicaciones de precaución: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 2 Oral
• Clase de almacenamiento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable