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SML1767

Sparstolonin B

≥98% (HPLC)

Sinónimos:

4,10-Dihydroxy-3H-pyrano[3,4,5-kl]xanthen-3-one, Sparstolenin B, SsnB

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Talla/SKUDisponibilidadPrecio
5 mg

Disponible para enviar HOYdesdeMILWAUKEE

$130.00
25 mg

Disponible para enviar HOYdesdeMILWAUKEE

$529.00

Acerca de este artículo

Fórmula empírica (notación de Hill):
C15H8O5
Número CAS:
1259330-61-4
Peso molecular:
268.22
UNSPSC Code:
51111800
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

$130.00

Disponible para enviar HOYDetalles

​
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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

OC(C=C1)=CC2=C1OC3=C4C(C(OC=C42)=O)=C(O)C=C3

InChI

1S/C15H8O5/c16-7-1-3-11-8(5-7)9-6-19-15(18)14-10(17)2-4-12(20-11)13(9)14/h1-6,16-17H

InChI key

DHSASSJDMAHICE-UHFFFAOYSA-N

Biochem/physiol Actions

Potent TLR2 and TLR4 antagonist that exhibits anti-inflammatory and anti-viral (anti-HIV) properties
Sparstolonin B (SsnB), an isocoumarin isolated from Sparganium stoloniferum and Scirpus yagara, is a potent TLR2 and TLR4 antagonist that exhibits anti-inflammatory and anti-viral (anti-HIV) properties. Sparstolonin B inhibits LPS induced inflammation in 3T3- L1 adipocytes, and reduces the body weight of rats fed with high fat diet. Sparstolonin B mitigates inflammation in nonalcoholic steatohepatitis (NASH) in mice model.
Sparstolonin B (SsnB) is a polyphenol. It has a structural features similar to xanthone and isocoumarin. SsnB exerts anti-inflammatory properties on mouse and human macrophages. SsnB can significantly reduce hypoxia–reoxygenation-induced inflammation of cardiomyocytes by blocking extracellular signal-regulated protein kinase (ERK1/2) and c-jun N-terminal kinases (JNK) signaling pathways. Thus, SsnB acts as a potent therapeutic for the treatment of myocardial ischemia–reperfusion (MIR) injury.

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Este artículo
SMB00155SML2808GF10716083
Sparstolonin B ≥98% (HPLC)

Sigma-Aldrich

SML1767

Sparstolonin B

Asparanin B ≥90% (LC/MS-ELSD)

Sigma-Aldrich

SMB00155

Asparanin B

Sparsentan ≥98% (HPLC)

Sigma-Aldrich

SML2808

Sparsentan

Iron boride powder, max. particle size 500 micron, weight 100 g

GF10716083

Iron boride

description

≥98% (HPLC)

description

≥90% (LC/MS-ELSD)

description

≥98% (HPLC)

description

powder, max. particle size 500 micron, weight 100 g

assay

≥98% (HPLC)

assay

≥90% (LC/MS-ELSD)

assay

≥98% (HPLC)

assay

-

form

powder

form

solid

form

powder

form

powder

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

-

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

-

solubility

DMSO: 10 mg/mL, clear

solubility

-

solubility

DMSO: 2 mg/mL, clear

solubility

-

color

white to beige

color

-

color

white to beige

color

-

Pictogramas

Exclamation mark
GHS07

Palabra de advertencia

Warning

Códigos de peligro

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Clase de almacenamiento

11 - Combustible Solids

¿Qué está pasando?

WGK 3

Punto de inflamación (°F)

Not applicable

Punto de inflamación (°C)

Not applicable

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Lot/Batch Number

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Questions

  1. Can IP injections of Sparstolonin B cross the blood-brain barrier into the neuroparenchyma in mice?

    1 answer

    1. This product is not tested for in vivo use. However, a literature review indicates that SsnB can cross the blood-brain barrier.

      Kindly review the following publications:

      Zhong Q, Zhou K, Liang QL, Lin S, Wang YC, Xiong XY, Meng ZY, Zhao T, Zhu WY, Yang YR, Liao MF, Gong QW, Liu L, Xiong A, Hao J, Wang J, Yang QW. Interleukin-23 Secreted by Activated Macrophages Drives γδT Cell Production of Interleukin-17 to Aggravate Secondary Injury After Intracerebral Hemorrhage. J Am Heart Assoc. 2016 Oct 11;5(10):e004340. doi: 10.1161/JAHA.116.004340. PMID: 27729335; PMCID: PMC5121525.

      Wang Y, Jiang S, Xiao J, Liang Q, Tang M. Sparstolonin B improves neurological outcomes following intracerebral hemorrhage in mice. Exp Ther Med. 2018 Jun;15(6):5436-5442. doi: 10.3892/etm.2018.6092. Epub 2018 Apr 24. PMID: 29844805; PMCID: PMC5958797.

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