SML1746

GS87

≥95% (HPLC)

• Sinónimos: 4-[5-[[(3-Phenyl-1,2,4-oxadiazol-5-yl)methyl]thio]-1,3,4-oxadiazol-2-yl]pyridine
• Fórmula empírica (notación de Hill): C₁₆H₁₁N₅O₂S
• Número de CAS: 919936-70-2
• Peso molecular: 337.36
• Número MDL: MFCD09295617
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329826052
• NACRES: NA.77

Propiedades

• Ensayo: ≥95% (HPLC)
• Formulario: powder
• color: white to beige
• solubilidad: DMSO: 10 mg/mL, clear
• temp. de almacenamiento: 2-8°C
• InChI: 1S/C16H11N5O2S/c1-2-4-11(5-3-1)14-18-13(23-21-14)10-24-16-20-19-15(22-16)12-6-8-17-9-7-12/h1-9H,10H2
• Clave InChI: HNTUWEZDVRVSFY-UHFFFAOYSA-N

Descripción

Acciones bioquímicas o fisiológicas

GS87 is a highly specific GSK3 (glycogen synthase kinase 3) inhibitor that induces extensive differentiation of AML cells. GS87 potently inhibits growth of AML cells in mice with little effect on normal bone marrow cells. GS87 causes terminal differentiation of AML cells.

GS87 regulates target proteins, that participates in the multiplication and differentiation of cells, much efficiently than lithium and SB. It helps to initiate mitogen-activated protein kinase (MAPK) signaling, that is required for its differentiation activity. GS87 is considered as a candidate for clinical acute myeloid leukemia (AML) differentiation therapy.

Highly specific GSK3 inhibitor that induces extensive differentiation of AML cells

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable