SML1729

SW044248

≥98% (HPLC)

• Sinónimos: 2-(5-Ethyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)-N-(2-methoxyphenyl)butanamide
• Fórmula empírica (notación de Hill): C₂₂H₂₃N₅O₂S
• Número de CAS: 522650-83-5
• Peso molecular: 421.52
• Número MDL: MFCD03487851
• Código UNSPSC: 12352202
• ID de la sustancia en PubChem: 329826043

Propiedades

• Ensayo: ≥98% (HPLC)
• Formulario: powder
• color: white to beige
• solubilidad: DMSO: 5 mg/mL, clear (warmed)
• temp. de almacenamiento: 2-8°C
• cadena SMILES: CCC(C(NC1=C(OC)C=CC=C1)=O)SC2=NC(N(CC)C3=C4C=CC=C3)=C4N=N2

Descripción

Acciones bioquímicas o fisiológicas

SW044248 is a cell permeable, indolotriazine-based compound that selectively inhibits topoisomerase 1 (Top 1), but not Top 2, catalyzed DNA decatenation in a manner distinct from that of camptothecin (Cat. Nos. 208925 & C9911). SW044248 is shown to exhibit antiproliferation efficacy against a subset of non-small-cell lung cancer (NSCLC) cultures (IC₅₀ <5 μM), including HCC4017 (IC₅₀ = 1.68 μM) as a result of DNA damage and apoptosis induction, while exhibiting little potency toward the non-cancerous HBEC30KT lung epithelial cells (IC₅₀ >10 μM) derived from the same patient as HCC4017.

SW044248 is a cell permeable, indolotriazine-based compound that selectively inhibits topoisomerase 1 (Top 1), but not Top 2.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable