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SML1529

Sigma-Aldrich

Erdosteine

≥98% (HPLC), powder, mucolytic agent

Sinónimos:

({2-Oxo-2-[(2-oxotetrahydro-3-thienyl)amino]ethyl}sulfanyl)acetic acid, 2-[[2-Oxo-2-[(tetrahydro-2-oxo-3-thienyl)amino]ethyl]thio]acetic acid

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50 MG
$99.90
250 MG
$402.30

$99.90

Precio de catálogo$111.00Ahorre 10 %

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50 MG
$99.90
250 MG
$402.30

About This Item

Fórmula empírica (notación de Hill):
C8H11NO4S2
Número de CAS:
84611-23-4
Peso molecular:
249.31
MDL number:
MFCD00867664
UNSPSC Code:
12352200
PubChem Substance ID:
329825946
NACRES:
NA.77

$99.90

Precio de catálogo$111.00Ahorre 10 %

En stockDetalles

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Nombre del producto

Erdosteine, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

S1CCC(C1=O)NC(=O)CSCC(=O)O

InChI

1S/C8H11NO4S2/c10-6(3-14-4-7(11)12)9-5-1-2-15-8(5)13/h5H,1-4H2,(H,9,10)(H,11,12)

InChI key

QGFORSXNKQLDNO-UHFFFAOYSA-N

General description

Erdosteine is a derivative of thiol, and is used in the treatment of chronic obstructive bronchitis, including acute infective exacerbation of chronic bronchitis.It consists of two blocked sulfhydryl groups, which are released following first-pass metabolism.[1]

Application

Erdosteine has been used as a mucolytic to study its protective effects on interleukin-1β-stimulated inflammation in rat chondrocytes in osteoarthritis models.[2]

Biochem/physiol Actions

Erdosteine is a mucolytic drug with expectorant and antitussive effects.
Erdosteine is a mucolytic drug with expectorant and antitussive effects. Erdosteine is quickly metabolized in vivo to free thiols which act as free radical scavengers. Erdosteine has also been shown to have antioxidant activity through the activation of Nrf2-dependent antioxidant genes and inhibition of pro-inflammatory cytokines.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
0000378482
0000349373
0000378482
0000275261
0000232347

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K L Dechant et al.
Drugs, 52(6), 875-881 (1996-12-01)
Erdosteine is a thiol derivative developed for the treatment of chronic obstructive bronchitis, including acute infective exacerbation of chronic bronchitis. Erdosteine contains 2 blocked sulfhydryl groups which are released following first-pass metabolism. The 3 active metabolites exhibit mucolytic and free
Yang Xi et al.
European journal of pharmacology, 873, 172925-172925 (2020-01-21)
Osteoarthritis (OA), a degenerative arthropathy, is featured with progressive degradation of cartilage and a chondrocyte inflammatory response. Erdosteine (ER) showed the anti-oxidant properties and various anti-inflammatory effects in various diseases. However, whether it protects against OA remains unknown. In this

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